| 王若冲,孟楚川,李景,等.基于“脾恶湿”理论探讨肠黏液屏障与嗜黏蛋白阿克曼菌的关系[J].浙江中医药大学学报,2024,48(10):1320-1324. |
| 基于“脾恶湿”理论探讨肠黏液屏障与嗜黏蛋白阿克曼菌的关系 |
| Exploring the Relationship between Intestinal Mucus Barrier and Akkermansia Muciniphila Based on“ Spleen Aversion to Damp?ness” Theory |
| DOI：10.16466/j.issn1005-5509.2024.10.021 |
| 中文关键词: 嗜黏蛋白阿克曼菌 肠道黏液屏障 肠道菌群 脾恶湿 脾虚生湿 厚肠法 卫气 黏蛋白 |
| 英文关键词: Akkermansia muciniphila intestinal mucus barrier intestinal flora spleen aversion to dampness spleen deficiency causing dampness theory of thicken intestine defensive Qi mucin |
| 基金项目:国家自然科学基金面上项目(82274385)；国家自然科学基金青年项目(82104706)；北京中医药大学揭榜挂帅项目(2023-JYB-JBQN-042) |
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| 中文摘要: |
| [目的] 基于中医“脾恶湿”理论，探讨嗜黏蛋白阿克曼菌(Akkermansia muciniphila，AKK)在构建和调节肠黏液屏障中的作用，及中医药治疗AKK相关肠道疾病中的应用。[方法] 以AKK对肠黏液屏障的调节机制为基础，阐述中医对肠黏液屏障的认识，并结合“脾恶湿”理论分析AKK与“脾”的关系，基于此讨论中医药治疗相关肠道疾病的思路。[结果] AKK对肠黏液屏障的构建具有重要作用，生理状态下，体现“脾为湿土”的特性，可通过降解黏蛋白，参与细胞通讯，增加肠黏液层厚度，增强肠上皮细胞完整性；病理状态下，“脾虚生湿”引起的菌群紊乱会导致AKK减少，进而引发肠黏液屏障损伤。中医药可通过“厚肠”法健脾，从而调节AKK，恢复肠道菌群与肠黏液屏障的稳态关系。[结论] AKK在构建和调节肠黏液屏障中发挥着重要作用，中医药治疗相关肠道疾病具有潜力，但需要更多研究来证实其药效机制。 |
| 英文摘要: |
| [Objective] Based on the traditional Chinese medicine theory of“ spleen aversion to dampness”， to investigate the role of Akkermansia muciniphila (AKK) in the construction and regulation of intestinal mucus barrier， as well as the application of traditional Chinese medicine(TCM) in the treatment of AKK-related intestinal diseases. [Methods] Based on the regulatory mechanism of AKK on the intestinal mucus barrier， this paper expounds the understanding of TCM on the intestinal mucus barrier， analyzes the relationship between AKK and the“ spleen” according to the theory of“ spleen aversion to dampness”， and discusses the treatment ideas of TCM for AKKrelated intestinal diseases. [Results] AKK plays an important role in the construction of the intestinal mucous barrier， reflecting the characteristics of“ spleen is damp soil” in the physiological state. It can increase the thickness of the intestinal mucous layer and enhance the integrity of intestinal epithelial cells through the degradation of mucin and participation in cell communication. In the pathological state， the bacterial disorder caused by“ spleen deficiency and dampness” leads to the reduction of AKK， which in turn causes damage to the intestinal mucous barrier. Traditional Chinese medicine can regulate AKK by“ Thickening the intestine” method to strengthen the Spleen， thereby restoring the steady-state relationship between the intestinal flora and the intestinal mucous barrier. [Conclusion] AKK plays an important role in the construction and regulation of the intestinal mucus barrier， and TCM has potential in the treatment of related intestinal diseases. However， more research is needed to confirm its pharmacodynamic mechanism. |
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