文章摘要
王安妮,鲁科达,夏璁,等.消瘀泄浊饮对CKD2~4期患者免疫调节功能及微炎症状态的影响[J].浙江中医药大学学报,2021,(1):51-55, 59.
消瘀泄浊饮对CKD2~4期患者免疫调节功能及微炎症状态的影响
The Effect of Xiaoyu Xiezhuo Decoction on the Immunoregulatory Function and the Microinflammatory State of Patients with Chronic Kidney Disease(Stage 2~4)
投稿时间:2020-06-30  
DOI:10.16466/j.issn1005-5509.2021.01.010
中文关键词: 消瘀泄浊饮  RORγt  Foxp3  慢性肾脏病  免疫调节功能  微炎症状态  免疫平衡  肾功能
英文关键词: Xiaoyu Xiezhuo Decoction  RORγt  Foxp3  chronic kidney disease  immunoregulatory function  microinflammatory state  immune balance  renal function
基金项目:浙江省自然科学基金项目(LY16H270007)
作者单位E-mail
王安妮 杭州市中医院 杭州 310007  
鲁科达 浙江中医药大学附属第一医院  
夏璁 浙江中医药大学附属第一医院  
朱梦洁 浙江绿城心血管病医院  
来洁 浙江中医药大学第一临床医学院  
何灵芝 浙江中医药大学附属第一医院 kid_doc@126.com 
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中文摘要:
      [目的]评估消瘀泄浊饮对慢性肾脏病(chronic kidney disease,CKD)2~4期患者免疫调节功能及微炎症状态的作用。[方法]选取80例CKD2~4期患者,随机分为两组:对照组40例,仅予基础治疗;治疗组40例,除基础治疗外加用中药汤剂消瘀泄浊饮治疗,1剂/d,分早晚两次服用。治疗12周后,比较两组治疗前后维甲酸相关孤儿受体γt(retinoid-related orphan receptor γt,RORγt)、叉头框转录因子p3(forkhead box p3,Foxp3)mRNA相对表达量,超敏C反应蛋白(high sensitivity-C reactive protein,hs-CRP)及肾功能相关指标水平变化情况。[结果]与治疗前比较,治疗组治疗后RORγt mRNA相对表达量下降(P<0.05),且低于对照组治疗后(P<0.05);Foxp3 mRNA相对表达量升高(P<0.05),且高于对照组治疗后(P<0.05)。与治疗前比较,治疗组治疗后hs-CRP水平下降(P<0.05),且低于对照组治疗后(P<0.05);血肌酐(serum creatinine,sCr)、血尿素氮(blood urea nitrogen,BUN)、24h尿蛋白定量(24-hour urinary protein quantity,24Upr)水平较前下降(P<0.05),其中sCr、BUN水平低于对照组治疗后(P<0.05)。[结论]消瘀泄浊饮能够调节免疫平衡,改善微炎症状态,延缓肾功能恶化,其机制可能与下调RORγt mRNA、上调Foxp3 mRNA水平、调节Th17/Treg平衡相关。
英文摘要:
      [Objective]To evaluate the effect of Xiaoyu Xiezhuo Decoction on the immunoregulatory function and microinflammation state.[Methods]Eighty patients were randomly divided into two groups: 40 cases in control group, which were given only basic treatment; 40 cases in treatment group, which were treated with Xiaoyu Xiezhuo Decoction in addition to basic treatment, 1 dose per day, taken twice in the morning and in the evening. After 12 weeks of treatment, the changes of relative expression quantity of retinoid-related orphan receptor γt(RORγt), forkhead box p3(Foxp3) mRNA, levels of high sensitivity-C reactive protein(hs-CRP) and related indicators of renal function between the two groups were compared. [Results]Compared with before treatment, relative expression quantity of RORγt mRNA of treatment group decreased after treatment(P<0.05), and it was lower than that of control group after treatment(P<0.05); relative expression quantity of Foxp3 mRNA of treatment group increased after treatment(P<0.05), and it was higher than that of control group after treatment(P<0.05). Compared with before treatment, level of hs-CRP, serum creatinine(sCr), blood urea nitrogen(BUN), 24-hour urinary protein quantity(24Upr) of treatment group decreased after treatment(P<0.05), and hs-CRP, sCr, BUN were lower than that of control group after treatment. [Conclusion]Xiaoyu Xiezhuo Decoction can regulate immune balance, improve the microinflammatory state,delay the deterioration of renal function, and the mechanism might be related to down-regulation of RORγt mRNA, up-regulation of Foxp3 mRNA and regulation of Th17/Treg balance.
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