文章摘要
孙谨怡,盛梅笑.基于黏膜免疫机制的IgA肾病中医认识及治疗进展[J].浙江中医药大学学报,2021,(3):306-309, 314.
基于黏膜免疫机制的IgA肾病中医认识及治疗进展
Traditional Chinese Medicine Recognition and Treatment of IgA Nephropathy Based on Mucosal Immune Mechanism
投稿时间:2020-03-11  
DOI:10.16466/j.issn1005-5509.2021.03.020
中文关键词: IgA肾病  黏膜免疫  发病机制  治疗进展  中医药  综述
英文关键词: immunoglobulinA nephropathy(IgAN)  mucosal immune  pathogenesis  treatment progress  traditional Chinese medicine(TCM)  review
基金项目:江苏省中医药领军人才项目(SLJ0205);科教强卫工程江苏省医学重点学科项目(K2016T24);南京中医药大学中医优势学科项目(ZYX03KF077)
作者单位E-mail
孙谨怡 南京中医药大学附属医院 南京 210029  
盛梅笑 南京中医药大学附属医院 南京 210029 dr.smx@163.com 
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中文摘要:
      [目的]总结免疫球蛋白A肾病(immunoglobulinA nephropathy,IgAN)黏膜免疫机制的中医认识及治疗进展。[方法]阅读近年来IgAN黏膜免疫机制相关的国内外文献,从IgAN的中医发病机制、辨证论治、外治法等方面对IgAN的黏膜免疫机制进行讨论分析。[结果]从中医角度来看,IgAN病位在肾,涉及咽、肺、脾、肠,“卫气不固”是本病的发病基础,“伏邪外发”是本病主要的致病条件,“湿热内蕴”是本病主要的病理因素及临床表现,咽肾同治、肺肾同治、脾肾同治、肠肾同治及外治疗法能缓解IgAN症状、改善相关实验室指标,从而保护肾功能并延缓肾功能进展。IgAN的病因病机、临床表现、治则治法等多方面均与现代医学的黏膜免疫机制相应。[结论]从中医角度探讨IgAN的黏膜免疫发病机制和内外治法,有利于进一步发挥中医药防治IgAN的优势,更好地指导临床应用,值得深入研究。
英文摘要:
      [Objective]To summarize the traditional Chinese medicine(TCM) understanding and treatment progress of mucosal immune mechanism in immunoglobulinA nephropathy(IgAN).[Methods]Through reading the domestic and foreign literatures about the mucosal immune mechanism of IgAN in recent years, the mucosal immune mechanism of IgAN was discussed and analyzed from the pathogenesis, syndrome differentiation and treatment, as well as external treatment and other aspects.[Results] From the perspective of TCM, the disease is located in the kidney, involving the pharynx, lung, spleen and intestine. “Defensive Qi instability” is the pathogenesis of the disease, “Incubated diseases induced” is the main pathogenic condition, “Damp heat accumulation” is the main pathological factors and clinical manifestations. Simultaneous treatment of the pharynx and kidney, simultaneous treatment of the lung and kidney, simultaneous treatment of the spleen and kidney, and simultaneous treatment of the intestine and kidney and external treatment can alleviate IgAN symptoms, and improve the related laboratory indexes,so as to protect renaltunction and delay the progress of renal function. The etiology, pathogenesis, clinical manifestations, treatment principles and methods of IgAN are corresponding to the mucosal immune mechanism of modern medicine. [Conclusion]To discuss the pathogenesis and internal and external treatment of IgAN from the perspective of TCM is conducive to further playing the advantages of TCM in the prevention and treatment of IgAN, and better guiding clinical application, which is worth further studying.
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