| 王梦倩,杨自梅,徐楚楚,等.中医清创术治疗非哺乳期乳腺炎疗效的Meta分析[J].浙江中医药大学学报,2022,46(2):173-180. |
| 中医清创术治疗非哺乳期乳腺炎疗效的Meta分析 |
| Meta-analysis of the Clinical Efficacy of Traditional Chinese Medical Debridement in Treating Non-puerperal Mastitis |
| DOI：10.16466/j.issn1005-5509.2022.02.012 |
| 中文关键词: 非哺乳期乳腺炎 中医清创术 中医外治法 切开引流 挂线疗法 临床疗效 患者满意度 Meta分析 |
| 英文关键词: non-puerperal mastitis traditional Chinese medical debridement traditional Chinese medicine external treatment incision and drainage thread drawing therapy clinical efficacy patient satisfaction Meta-analysis |
| 基金项目:国家自然科学基金面上项目(82074438) |
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| 中文摘要: |
| [目的] 通过Meta分析，对比中医清创术与西医治疗非哺乳期乳腺炎的有效率、复发率、疼痛、心理状态、日常生活情况之间的差异。[方法] 通过计算机检索PubMed、Embase、The Cochrane Library、中国生物医学文献数据库、中国知网数据库、万方数据库、维普中文期刊数据库中自数据库建立至2020年12月20日的中医清创术治疗非哺乳期乳腺炎的随机对照试验(randomized controlled trial，RCT)文献，检索语言不限，结局指标包括临床疗效、复发率、疼痛评分、日常生活质量评分等。文献质量评价由来自于Cochrane协作网的偏倚风险评估完成。[结果] 最终符合标准的RCT文献共10篇，均为中文文献，以中医清创术组为试验组，共328例；西医治疗组为对照组，共329例。Meta分析结果显示，中医清创术治疗非哺乳期乳腺炎有效率优于西医治疗[比值比(odds ratio，OR)=4.24，95%置信区间(confidence interval，CI)(2.54，7.10)，Z=5.50，P＜0.00001]。同时，中医清创术在提高患者日常生活能力[均数差(mean deviation，MD)=20.23，95%CI(19.03，21.42)，Z=33.12，P＜0.00001]、改善患者心理状态[MD=28.65，95%CI(15.54，20.17)，Z=4.28，P＜0.0001]等方面均优于西医治疗。两组患者疼痛评分[MD=-7.66，95%CI(-38.10，22.78)，Z=0.49，P=0.62]、复发率[OR=0.53，95%CI(0.19，1.48)，Z=1.21，P=0.22]对比，差异无统计学意义。发表偏倚分析表明，所包含的文献不存在偏倚。[结论] 中医清创术治疗非哺乳期乳腺炎能更好地提高临床疗效，改善患者心理状态及日常生活质量，具有一定推广应用价值。 |
| 英文摘要: |
| [Objective] To compare the efficacy， recurrence rate， pain， mentation and activity of daily living of traditional Chinese medical(TCM) debridement with western therapy in treating non-puerperal mastitis.[Methods] From PubMed， EMbase，the Cochrane Library， China Biology Medicine disc(CBMdisc)，China National Knowledge Infrastructure(CNKI)，Wanfang Database， China Science and Technology Journal Database， qualified randomized controlled trials(RCT) were retrieved which involved TCM debridement in assisting non-puerperal mastitis. Search time limit was from the establishment date of database to 20th December， 2020， and the search language was not limited. Outcomes should include at least one of clinical efficacy， recurrence rate， pain score， and quality of daily life score. The literature quality was evaluated by the Cochrane Collaboration‘s risk assessment tool for reliance. [Results] There were 10 RCT literatures that met the criteria which were all in Chinese， and 328 cases treated by TCM debridement were assigned as experimental group， other 329 cases treated by western medicine were assigned as control group. The results of statistical analysis showed that the total effective rate of experimental group was higher than that of control group[odds ratio(OR)=4.24， 95% confidence interval(CI)(2.54，7.10)， Z=5.50， P＜0.00001]. Simultaneously， experimental group was superior than control group in terms of quality of life[mean deviation(MD)=20.23， 95%CI(19.03， 21.42)， Z=33.12， P＜0.00001]， mentation[MD=28.65， 95%CI(15.54， 20.17)， Z=4.28， P＜0.0001]. However， there were no differences in the pain score[MD=-7.66， 95%CI(-38.10， 22.78)， Z=0.49， P=0.62] and recurrence rate[OR=0.53， 95%CI(0.19， 1.48)， Z=1.21， P=0.22] between the two groups. Publication bias analysis showed that there was no bias for the literature included. [Conclusion] TCM debridement in the treatment of non-puerperal mastitis can better improve the clinical curative effect， improve the mentation state and quality of daily life of patients，and has certain clinical application value. |
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