文章摘要
基于活血化瘀理论的中药配伍(丹红注射液为示范)防治缺血性脑损伤炎症反应的作用机制
Mechanism of Chinese Herbal Medicine Based on the Theory of Promoting Blood Circulation and Removing Blood Stasis in Preventing and Treating Inflammatory Response of Ischemic Brain Injury
投稿时间:2019-06-22  修订日期:2019-06-22
DOI:
中文关键词: 活血化瘀  丹参  红花  脑缺血再灌注  炎症反应
英文关键词: Blood circulation  Salvia miltiorrhiza Bunge  Carthamus tinctorius L.  Cerebral Ischemia Reperfusion  Inflammation
基金项目:国家自然科学基金(81503491)
作者单位E-mail
张琛 陕西中医药大学 793974934@qq.com 
朱慧渊 陕西中医药大学 498734724@qq.com 
王江 陕西中医药大学  
韦克克 陕西中医药大学  
万海同 浙江中医药大学  
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中文摘要:
      炎症反应在缺血性脑损伤相关病理生理的过程起到一定程度的影响作用,基于中医活血化瘀理论的瘀血证与炎症反应的关系密不可分。瘀血证与炎症相关性研究结果表明,瘀血证的病理实质包括了多种致炎因子造成组织器官水肿、血栓形成及相关炎症通路等一系列的病理变化,而活血化瘀类方药的作用机制则主要体现在抗炎、免疫调节与改善微循环等方面。本文拟开展活血化瘀中药配伍(丹红注射液为示范)抗缺血性脑损伤炎症反应的作用机制研究,为临床缺血性脑病的新药开发提供理论基础。
英文摘要:
      The Inflammation plays a certain role in the pathophysiological process of ischemic brain injury. The relationship between Inflammation and blood stasis syndrome based on TCM theory of promoting blood circulation and removing blood stasis is inseparable. The results of the study on the relationship between blood stasis syndrome and inflammation indicate that the pathological essence of blood stasis syndrome includes a series of pathological changes such as tissue edema, thrombosis and related inflammatory pathway caused by various proinflammatory factors, and the mechanism of action of blood-activating and stasis-removing prescriptions is Mainly reflected in anti-inflammatory, immune regulation and improvement of microcirculation. We will intend to carry out research on the mechanism of anti-ischemic brain injury inflammatory response by the combination of traditional Chinese medicine for promoting blood circulation and removing blood stasis (Danhong injection as a demonstration), and provides a theoretical basis for the development of new drugs for clinical ischemic encephalopathy.
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