| 詹倩,胡广操,王敏龙,等.中药对照软骨保护剂改善膝骨关节炎功能活动的系统评价[J].浙江中医药大学学报,2019,43(2):199-204. |
| 中药对照软骨保护剂改善膝骨关节炎功能活动的系统评价 |
| Efficacy of Chinese Herbal Medicines versus Chondroprotective Agents in Improving Knee Joint Function of Knee Osteoarthritis:A Systematic Review |
| DOI：10.16466/j.issn1005-5509.2019.02.018 |
| 中文关键词: 膝骨性关节炎 中药 软骨保护剂 功能活动 系统评价 |
| 英文关键词: knee osteoarthritis Chinese herbal medicines Chondroprotective Agents functional activity systematic review |
| 基金项目:绍兴市卫生计生科技计划项目(2016CX013) |
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| 中文摘要: |
| [目的]系统评价中药对照软骨保护剂改善膝骨关节炎的功能活动及药物安全性。[方法]检索中国知识资源总库(Chinese National Knowledge Infrastructure, CNKI)、维普期刊数据库(VIP Journal Database，VIP)、万方数据知识服务平台(Wan-fang Data Knowledge Service Platform，Wan-Fang)、中国生物医学文献数据库(China Biology Medicine, CBM)中有关中药与软骨保护剂的随机和半随机对照临床试验，检索时限至2018年6月30日。由2名研究者依据纳入排除标准独立筛选文献、提取数据、并行文献质量评价，运用RevMan5.3软件进行统计分析。[结果]共纳入9项研究，合计689例膝骨性关节炎患者。6项研究因较大异质性仅采用描述性分析，2项研究Meta分析结果显示口服中药汤剂膝关节功能活动评分与软骨保护剂比较有统计学差异[SMD=-0.33,95%CI(-0.62, -0.33), P<0.05]。[结论]口服中药汤剂在约3个月时对膝关节功能活动的改善优于软骨保护剂，但基于现有研究缺陷，结论尚需高质量的随机对照试验予以证实。 |
| 英文摘要: |
| [Objective] To assess the efficacy and safety of Chinese herbal medicine versus Chondroprotective Agents in improving knee joint function of knee osteoarthritis.[Methods] CNKI, VIP, Wan-Fang, and CBM databases were searched up to November 30, 2014 for relevant randomized and quasi-randomized controlled clinical trials of addressing the efficacies of Chinese herbal medicines versus Chondroprotective Agents in the treatment of knee osteoarthritis. Two reviewers independently selected literature, extracted data, and assessed the quality of included trials. Data extraction from eligible studies was pooled and meta-analyzed using RevMan 5.3 software.[Results] A total of 9 studies involving 689 patients with knee osteoarthritis were included. The characteristics of six studies were summarized through descriptive analysis, because of the significant heterogeneity.The Meta-analysis results of two studies indicated that Chinese herbal medicines had better impact on measure of knee joint function in knee osteoarthritis patients in comparison to the Chondroprotective Agents[SMD=-0.33,95%CI(-0.62, -0.33),P<0.05].[Conclusion] The effect of Chinese herbal medicines on knee joint function is better than Chondroprotective Agents at about 3 months. However, owing to the research defects, further work based on high-quality randomized controlled trials is needed to determine the role of Chinese herbal medicines in the treatment of knee osteoarthritis. |
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