| 魏丽萍,方晓江,刘昭,等.黄芪失笑散对介入术后ACS患者血管内皮功能及炎症因子的影响研究[J].浙江中医药大学学报,2019,43(3):245-248. |
| 黄芪失笑散对介入术后ACS患者血管内皮功能及炎症因子的影响研究 |
| Effect of Huangqi Shixiao Powder on Vascular Endothelial Function and Inflammatory Factor in ACS Patients after Percutaneous Coronary Intervention |
| DOI：10.16466/j.issn1005-5509.2019.03.010 |
| 中文关键词: 黄芪失笑散 急性冠脉综合征 内皮功能 炎症因子 hs-CRP TNF-α |
| 英文关键词: Huangqi Shixiao Powder acute coronary syndrome endothelial function inflammatory factors hs-CRP TNF-α |
| 基金项目:浙江省中医药科技计划项目(2013ZB091、2016ZA148) |
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| 中文摘要: |
| [目的]了解黄芪失笑散对介入术后急性冠脉综合征(acute coronary syndrome，ACS)患者的疗效，并探讨其对内皮功能及炎症因子的影响。[方法] 选取2016年1月至2018年1月杭州市中医院心内科住院的ACS患者60例，以随机数字表法分为观察组及对照组，每组各30例。对照组患者行经皮冠脉介入治疗(percutaneous coronary intervention，PCI)后予以常规治疗，观察组在此基础上予加用黄芪失笑散，1日1剂，分两次服用。两组患者连续治疗3个月后，统计两组临床症状疗效，比较两组中医证候积分改善情况；检测并比较两组治疗前后内皮功能指标内皮素-1(endothelin-1，ET-1)、一氧化氮(nitric oxide，NO)及炎症因子高敏C反应蛋白(high sensitivity-C reactive protein，hs-CRP)、肿瘤坏死因子-α(tumor necrosis factor-α，TNF-α)的变化。[结果]观察组总有效率优于对照组(P＜0.05)；两组患者中医证候积分均较治疗前下降(P＜0.05)，且观察组疗效明显优于对照组(P＜0.05)。两组患者ET-1水平均较治疗前下降，NO水平则较治疗前上升，差异均有统计学意义(P＜0.05)，观察组治疗后ET-1水平低于对照组，NO水平高于对照组，差异有统计学意义(P＜0.05)。两组患者hs-CRP及TNF-α水平均较治疗前下降(P＜0.05)，观察组优于对照组，差异有统计学意义(P＜0.05)。[结论] 黄芪失笑散可改善ACS患者介入术后临床症状，其机制可能与改善血管内皮功能及抑制炎症因子释放有关。 |
| 英文摘要: |
| [Objective] To investigate the therapeutic effect of Huangqi Shixiao Powder on acute coronary syndrome(ACS) patients after percutaneous coronary intervention(PCI), and to explore its mechanism in influencing endothelial function and inflammatory factors. [Methods] Sixty patients with ACS in the Department of Cardiology of Hangzhou Hospital of Traditional Chinese Medicine from January 2016 to January 2018 were randomly divided into observation group and control group with 30 cases in each group. Control group was treated with routine medicine after PCI. On the basis of this, observation group was treated with Huangqi Shixiao Powder, one dose a day, twice a day. After 3 month of continuous treatment, the clinical efficacy of two groups was statistically analyzed, and the improvement of TCM syndrome score was compared. Expression of endothelin-1(ET-1), nitric oxide(NO), high sensitivity-C reactive protein(hs-CRP) and tumor necrosis factor-α(TNF-α)were detected, and compared before and after treatment. [Results] The total effective rate of clinical symptoms in observation group was better than that in control group(P＜0.05). The scores of TCM syndromes in the two groups were lower than those before treatment(P＜0.05), and the curative effect in observation group was better than that in control group(P＜0.05). The levels of ET-1 in two groups were lower than those before treatment, while the levels of NO were higher than those before treatment, and there was statistical significance(P＜0.05). The decrease of ET-1 and the increase of NO in observation group were significantly higher than those in control group, and the difference was statistically significant(P＜0.05).The levels of hs-CRP and TNF-α in two groups were lower than those before treatment(P＜0.05). After treament, the level of ET-1 in observation group was lower than control group, the level of NO in observation group was higher than control group and the difference was statistically significant(P＜0.05).[Conclusion] Huangqi Shixiao Powder can improve the clinical symptoms of patients with ACS after PCI, and the mechanism may be related to improving vascular endothelial function and inhibiting the release of inflammatory factors. |
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