| 吴叶琪,项亚楠,房军帆,等.杏仁核NPS/NPSR神经肽系统参与痛情绪过程的研究进展[J].浙江中医药大学学报,2019,43(3):286-290. |
| 杏仁核NPS/NPSR神经肽系统参与痛情绪过程的研究进展 |
| The Research Progress on the Involvement of NPS/NPSR System in the Amygdala in the Emotional Processing of Pain |
| DOI：10.16466/j.issn1005-5509.2019.03.022 |
| 中文关键词: 杏仁核 神经肽S/神经肽S受体系统 痛情绪 研究进展 |
| 英文关键词: amygdala NPS/NPSR neuropeptide system pain emotion research progress |
| 基金项目: |
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| 摘要点击次数: 1849 |
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| 中文摘要: |
| [目的]综述近年来杏仁核(neuropeptide S, NPS/NPSR)神经肽系统参与痛情绪过程的研究进展。[方法]通过中国知网、万方、PubMed 等数据库检索近年来国内外关于杏仁核NPS/NPSR神经肽系统参与痛情绪相关反应的实验研究文献，总结杏仁核NPS/NPSR神经肽系统参与痛情绪过程的研究概况。[结果]①杏仁核活动与痛情绪密切相关，抑制杏仁核活动可以减轻甚至消除疼痛相关情绪行为；②NPS/NPSR神经肽系统在杏仁核的信号传输机制中发挥了重要的作用:NPS通过杏仁核BLA环路进行信息处理，从而实现对疼痛负性情绪的调控。[结论]NPS/NPSR神经肽系统通过杏仁核信息传递相关通路参与调控痛情绪行为，作用显著。深入研究NPS/NPSR神经肽系统在痛情绪行为中的神经生物学机制，有望为临床治疗痛情绪提供新的治疗思路与手段。 |
| 英文摘要: |
| [Objective] To summarize the research progress on the involvement of NPS/NPSR neuropeptide system in the amygdala in the emotional processing of pain.[Methods] By querying the nearly years of the domestic and foreign literature about the involvement of NPS/NPSR in the amygdala in the pain-related reactions from CNKI,Wan Fang,PubMed,etc,summarizing the overview on studies of the effect of NPS/NPSR in the amygdala in the emotional processing of pain.[Results](1)Activity of the amygdala is closely related to pain emotions. Pain-related emotional behaviors will be alleviated,even eliminated,if the activity of amygdala is inhibited.(2)The NPS/NPSR neuropeptide system plays an important role in the signal transmission mechanism of the amygdala: NPS deals with the information via BLA circuit of the amygdala to regulate the negative emotions.[Conclusion]The NPS/NPSR participates in the regulation of pain-related emotional behavior through the circuit of amygdala.In-depth studies on the neurobiological mechanism of NPS/NPSR neuropeptide system in pain-related behaviors are expected to provide new therapeutic ideas and means for clinical treatment of pain emotion. |
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