| 蒋婴,张蔚苓.高危型HPV感染患者Th1/Th2平衡与中医体质相关性研究[J].浙江中医药大学学报,2019,43(7):669-672. |
| 高危型HPV感染患者Th1/Th2平衡与中医体质相关性研究 |
| Correlation Between Th1/Th2 Balance and TCM Constitution in Patients with Cervical HR-HPV Infection |
| DOI：10.16466/j.issn1005-5509.2019.07.010 |
| 中文关键词: HR-HPV Th1/Th2 中医体质 IL-2 IFN-γ IL-4 IL-10 |
| 英文关键词: HR-HPV Th1/Th2 TCM constitution IL-2 IFN-γ IL-4 IL-10 |
| 基金项目:宁波市医学科技计划项目(2016A20)；宁波市中医重点学科中西医结合妇科(2016-Z03) |
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| 中文摘要: |
| [目的]通过观察宫颈高危型人乳头瘤病毒(high-risk human papillomavirus，HR-HPV)感染患者与健康女性中医体质分布、阴道灌洗液细胞因子水平，以及Th1/Th2平衡情况，探讨宫颈HR-HPV感染患者Th1/Th2平衡与中医体质的相关性。[方法]选择HR-HPV感染患者(感染组)与健康女性(对照组)各60例，应用《KY3H中医体质辨识表》 进行体质辨识，采用酶联免疫吸附(enzyme linked immunosorbent assay，ELISA)法检测各组患者阴道灌洗液中白细胞介素-2(interleukin-2，IL-2)、γ-干扰素(interferon-γ，IFN-γ)、白细胞介素-4(interleukin-4，IL-4)、白细胞介素-10(interleukin-10，IL-10)的水平。比较两组中医体质分布情况、阴道灌洗液细胞因子水平，并比较两组中偏颇体质人群的阴道灌洗液细胞因子水平以及Th1/Th2细胞因子平衡情况。[结果]感染组中偏颇体质占主导(63.33%)，且与对照组比较明显增高(P＜0.05)；感染组IL-2、IFN-γ水平明显低于对照组，IL-4、IL-10明显高于对照组，差异均有统计学意义(P＜0.01)；偏颇体质人群中，感染组IL-2、IFN-γ水平低于对照组，其中IL-2差异无统计学意义(P＞0.05)， IFN-γ差异有统计学意义(P＜0.01)；IL-4、IL-10水平高于对照组，差异均有统计学意义(P＜0.05，P＜0.01)。偏颇体质Th1/Th2细胞因子比较，感染组IL-2/IL-4、IL-2/IL-10、IFN-γ/IL-4、IFN-γ/IL-10比值均低于对照组，差异有统计学意义(P＜0.05)。[结论]偏颇体质女性更易感染HR-HPV，且阴道灌洗液细胞因子Th1/Th2平衡向Th2漂移。 |
| 英文摘要: |
| [Objective] To explore the correlation between Th1/Th2 balance and TCM constitution in by observing the distribution of TCM constitution, the level of cytokine in the vaginal lavage fluid and the balance of Th1/Th2 in women with cervical high-risk human papillomavirus(HR-HPV) infection and healthy women.[Methods] Sixty patients with cervical HR-HPV infection(infection group) and sixty healthy women(control group) were selected. TCM constitution identification through the “KY3H Chinese Medicine Constitution Identification Table”. The levels of interleukin-2 (IL-2), interferon-γ(IFN-γ), interleukin-4(IL-4) and interleukin-10(IL-10) in vaginal lavage fluid were detected by enzyme linked immunosorbent assay(ELISA). TCM constitution, the level of cytokine in vaginal lavage fluid, and the balance of Th1/Th2 cytokine was compared in the two groups and in people with biased constitution. [Results] Biased constitution was dominant in infection group(63.33%), and it was significantly higher than that in control group(P＜0.05). The level of IL-2 and IFN-γ were significantly lower in infection group than control group, IL-4 and IL-10 were significantly higher than control group(P＜0.01). In the biased constitution, the level of IL-2 and IFN-γ in infection group was lower than that of control group, and there was no significant difference in IL-2(P＞0.05), and the difference of IFN-γ was statistically significant(P＜0.01). The levels of IL-4 and IL-10 were higher than those in control group(P＜0.05,P＜0.01). Comparison of Th1/Th2 cytokine in biased constitution, the ratios of IL-2/IL-4, IL-2/IL-10, IFN-γ/IL-4 and IFN-γ/IL-10 in infection group were lower than control group(P＜0.05). [Conclusion] Women with biased constitution are more susceptible to HR-HPV, and the balance of cytokine Th1/Th2 in vagina lavage fluid is drifting towards to Th2. |
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