文章摘要
孙蓬远,高明利.气阴两虚型类风湿关节炎的临床特点研究[J].浙江中医药大学学报,2019,43(7):690-692, 701.
气阴两虚型类风湿关节炎的临床特点研究
The Clinical Characteristics of Rheumatoid Arthritis with Qi and Yin Deficiency
DOI:10.16466/j.issn1005-5509.2019.07.016
中文关键词: 类风湿关节炎  气阴两虚型  临床特点  证候特点  处方特点  病证结合
英文关键词: rheumatoid arthritis  Qi and Yin deficiency syndrome  clinical characteristics  syndrome characteristics  prescription characteristics  combination of disease and syndrome
基金项目:辽宁省中医药临床学(专)科能力建设项目(2017032)
作者单位E-mail
孙蓬远 辽宁中医药大学附属医院 沈阳 110032  
高明利 辽宁中医药大学附属医院 沈阳 110032 gmllnzy@139.com 
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中文摘要:
      [目的] 探讨气阴两虚型类风湿关节炎(rheumatoid arthritis,RA)的临床特点。[方法]选择2015年1月至2017年12月就诊于辽宁中医药大学附属医院的气阴两虚型RA患者,提取、记录并统计相关信息,探讨本证型患者年龄、性别、病程、合并疾病,以及炎症指标C反应蛋白(C reactive protein,CRP)、血沉(erythrocyte sedimentation rate,ESR)等临床特点,并与其他证型进行比较。[结果]气阴两虚型RA多见于中老年女性患者,多数病程大于10年;病情活动度较大多数证型低;常合并干燥综合征、慢性病性贫血、骨关节炎、骨质疏松、肺间质纤维化、2型糖尿病等疾病;患者的临床主要症状及体征为关节肿痛、晨起僵硬、口眼干涩、神疲乏力、脉细无力、肌肉酸痛、腰膝酸软、气短咳嗽、消瘦等;炎症指标轻度升高;处方的中药方剂以益气养阴中药配合活血通络中药为主,西医治疗中糖皮质激素的应用比例明显高于其他证型,联合用药中白芍总苷胶囊比例高于其他植物药,生物制剂应用比例较低。[结论]气阴两虚型RA患者的年龄、性别、病程、病情活动度、合并疾病、炎症指标、临床用药具有一定的特点。
英文摘要:
      [Objective] To explore the clinical characteristics of rheumatoid arthritis(RA) with Qi and Yin deficiency. [Methods] RA patients with Qi and Yin deficiency in Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January 2015 to December 2017 were collected, relevant information and record were extracted and statistically analyzed to explore the clinical characteristics, including age, gender, disease course, concomitant diseases, inflammatory indicators C reactive protein(CRP) and erythrocyte sedimentation rate(ESR), and compared with other syndrome types. [Results] The syndrome of RA with Qi and Yin deficiency is more common in middle-aged and elderly women, and the course of disease is more than 10 years. The disease activity is lower than most syndromes, often associated with Sjgren’s syndrome, chronic anemia, osteoarthritis, osteoporosis, pulmonary interstitial fibrosis, type 2 diabetes and other diseases. The main clinical symptoms and signs are swelling and pain of the joints, stiffness in the morning, dry mouth and eyes, fatigue, thready and weak pulse, muscle soreness, weak waist and knee, short breath, cough and emaciation, etc; and inflammation index is elevated slightly. The prescription of traditional Chinese medicine is mainly for invigorating Qi, nourishing Yin and invigorating blood circulation. The proportion of glucocorticoid use is significantly higher than that of other syndromes, the proportion of Paeony Capsules use in combination medication is higher than other plant drugs, and the proportion of biological agents is lower. [Conclusion] The age, gender, course of disease, disease activity, concomitant disease, inflammatory indicator and prescription of RA patients with Qi and Yin deficiency have certain characteristics.
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