| 陈灵洁,余莹,熊文生.归脾汤辅助治疗缺铁性贫血随机对照实验的Meta分析[J].浙江中医药大学学报,2019,43(12):1368-1376. |
| 归脾汤辅助治疗缺铁性贫血随机对照实验的Meta分析 |
| A Meta-analysis of Randomized Controlled Trials of Guipi Decoction in Assisting Treatment of Iron Deficiency Anemia |
| DOI：10.16466/j.issn1005-5509.2019.12.015 |
| 中文关键词: 归脾汤 缺铁性贫血 随机对照实验 Meta分析 |
| 英文关键词: Guipi Decoction iron deficiency anemia randomized controlled trial Meta-analysis |
| 基金项目: |
|
| 摘要点击次数: 1789 |
| 全文下载次数: 1119 |
| 中文摘要: |
| [目的]系统评价归脾汤辅助治疗缺铁性贫血的有效性及安全性。[方法]计算机检索外文数据库Cochrane Library、Pubmed、EMbase，以及国内数据库万方数据库、维普数据库、中国学术期刊全文数据库(China National Knowledge Infrastructure，CNKI)、中国生物医学文献数据库(China Biology Medicine，CBM)，纳入归脾汤辅助治疗缺铁性贫血的随机对照研究，检索时限均从建库至2018年11月，检索语言不限。结局指标至少应包括临床疗效、血红蛋白含量、红细胞计数、血清铁含量、血清铁蛋白含量其中的一个。文献质量评价由来自于Cochrane协作网的偏倚风险评估工具及Jadad质量评价量表完成。[结果]最终符合纳入标准的文献共15篇，总例数1 241例，包括实验组(归脾汤联合西药组)629例，对照组(单纯西药组)612例。Meta分析显示:归脾汤联合西药治疗缺铁性贫血的临床疗效显著(MD=0.14，95%CI:0.08～0.24，P＜0.00001)，并且在提升血红蛋白含量(MD=7.41，95%CI:6.27～8.56，P＜0.00001)、红细胞计数(MD=0.34，95%CI:0.04～0.65，P=0.03)、血清铁含量(SMD=0.56，95%CI:0.07～1.04，P=0.03)、血清铁蛋白含量(SMD=2.22，95%CI:0.26～4.18，P=0.03)方面明显优于单纯西药组。[结论]归脾汤辅助治疗缺铁性贫血能够更好地改善患者的贫血症状，具有良好的应用前景。但由于纳入文献方法学质量和样本量的局限性，其疗效仍需要设计严谨的多中心、大规模、高标准化的研究来进一步验证。 |
| 英文摘要: |
| [Objective] To systematically evaluate the efficacy and safety of Guipi Decoction in assisting treatment of iron deficiency anemia(IDA). [Methods] From the Cochrane Library, Pubmed, EMbase, Wanfang Database, Chinese Scientifc Journals Database, China National Knowledge Infrastructure(CNKI), China Biology Medicine(CBM),qualified randomized controlled trials were retrieved which involving Guipi Decoction in assisting treatment of IDA. Search time limit was from the establishment of database to November 2018, and the search language was not limited. Outcomes should include at least one of clinical efficacy, hemoglobin content, red blood cell count, serum iron and serum ferritin content. Literature quality is evaluated by the Cochrane Collaboration's risk assessment tool for reliance and Jadad quality scale. [Results] There were a total of 15 articles that met the inclusion criteria. The total number of cases was 1 241, including 629 cases of experimental group(Guipi Decoction combined with western medicine group) and 612 cases of control group(western medicine alone group). Meta-analysis results showed that Guipi Decoction combined with western medicine treatment of IDA had a significant clinical effect(MD=0.14, 95%CI:0.08～0.24, P＜0.00001), and it was significantly superior to western medicine treatment in increasing hemoglobin content(MD=7.41, 95%CI:6.27～8.56, P＜0.00001), red blood cell count(MD=0.34, 95%CI:0.04～0.65, P=0.03), serum iron content(SMD=0.56, 95%CI:0.07～1.04, P=0.03), serum ferritin content(SMD=2.22, 95%CI:0.26～4.18, P=0.03). [Conclusion] The assisting treatment of IDA with Guipi Decoction can relieve the patient's anemia symptoms better. The clinical curative effect is significant and has a good application prospect. However, due to the limitations of the literature methodological quality and sample size, it is still necessary to design a rigorous multi-center, large-scale, high-standardization study to further verify. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|