| 章勤,杨柳青,陈墨林婧,等.何氏养巢颗粒治疗肾虚型卵巢储备功能下降的临床观察[J].浙江中医药大学学报,2020,44(5):434-437, 446. |
| 何氏养巢颗粒治疗肾虚型卵巢储备功能下降的临床观察 |
| The Clinical Observation on Diminished Ovarian Reserve of Kidney Deficiency Syndrome Treated with HE’s Yangchao Granule |
| DOI：10.16466/j.issn1005-5509.2020.05.006 |
| 中文关键词: 何氏养巢颗粒 肾虚型 卵巢储备功能下降 血清指标 临床疗效 |
| 英文关键词: HE's Yangchao Granule kidney deficiency type diminished ovarian reserve serum index clinical effect |
| 基金项目:浙江省中医药重点研究项目(2017ZKL004) |
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| 中文摘要: |
| [目的]观察何氏养巢颗粒治疗肾虚型卵巢储备功能下降(diminished ovarian reserve，DOR)的临床疗效。[方法]将110例DOR患者随机分为治疗组和对照组，每组55例。治疗组口服何氏养巢颗粒，每日1剂，早晚分服；对照组口服脱氢表雄酮(dehydroepndrosterone，DHEA)，每日3次，每次1粒，疗程均为3个月经周期，观察患者治疗前后月经情况、临床症状、促卵泡生成素(follicle-stimulating hormone，FSH)、FSH/LH值、抗菌勒管激素(anti-Müllerian hormone，AMH)、窦卵泡计数(antral follicle count，AFC)的变化。两组患者治疗前后检测血、尿常规及肝肾功能等实验室指标，并观察可能出现的其他不良事件。[结果]治疗组总有效率为90.4%，对照组总有效率为64.7%，两组疗效比较有统计学差异(P＜0.05)。两组患者治疗后FSH水平、FSH/LH值均有改善，与治疗前比较有统计学差异(P＜0.05)，治疗组患者治疗前后AMH水平及AFC有统计学差异(P＜0.05)，而对照组无统计学差异(P＞0.05)。组间比较显示，治疗组在提高AMH水平、降低FSH水平及FSH/LH值、增加AFC上均优于对照组(P＜0.05)。两组患者治疗过程中未发现不良反应，治疗前后患者血、尿常规及肝肾功能均正常。[结论]何氏养巢颗粒治疗DOR疗效确切，可以通过降低血清FSH水平，提高AMH水平，增加窦卵泡数量，促进卵泡发育和排卵，在防治卵巢功能衰退、改善伴随症状等方面安全有效，值得进一步研究。 |
| 英文摘要: |
| [Objective] To observe the clinical effect on the diminished ovarian reserve(DOR) of kidney-deficiency treated with HE's Yangchao Granule. [Methods]One hundred and ten patients were randomly divided into treatment group and control group，55 cases in each group.In the treatment group， HE's Yangchao Granule was taken orally one dose per day， half dose in the morning and half dose in the evening. In control group， dehydroepndrosterone(DHEA) was taken orally three times a day， one capsule per time. The course of treatment in both groups was three menstrual cycles.The menstrual conditions， clinical symptoms， serum follicle-stimulating hormone(FSH)，FSH/luteinizing hormone(LH)，anti-Müllerian hormone(AMH)，antral follicle count(AFC) were observed before and after treatment. The blood， urine routine test， liver and kidney function and other laboratory indicators were detected， and other possible adverse events were observed before and after treatment.[Results] The total effective rate of the treatment group was 90.4%， and the total effective rate of the control group was 64.7%， and the difference was statistically significant(P＜0.05). After treatment， the FSH and FSH/LH of the two groups were improved(P＜0.05). There were significant differences in AMH and AFC before and after treatment in the treatment group(P＜0.05)， but no significant differences in the control group(P＞0.05).No adverse reactions were found in the two groups. The blood， urine routine test and liver and kidney function were normal before and after treatment. [Conclusion]The therapeutic effect of HE's Yangchao Granule on DOR is definite. It can reduce serum FSH， increase AMH and AFC， promote follicular development and ovulation. It is safe and effective in preventing and treating ovarian function decline， relieving accompanying symptoms and worth to further study. |
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