| 李明花,董志毅,苏晋梅,等.益气养阴解毒方延长广泛期小细胞肺癌患者一线化疗疾病无进展生存期的研究[J].浙江中医药大学学报,2020,44(11):1090-1094, 1098. |
| 益气养阴解毒方延长广泛期小细胞肺癌患者一线化疗疾病无进展生存期的研究 |
| Study on Prolonging Progression-free Survival of First-line Chemotherapy in Patients with Extensive-stage Small Cell Lung Cancer by Yiqi Yangyin Jiedu Formula |
| DOI：10.16466/j.issn1005-5509.2020.11.013 |
| 中文关键词: 小细胞肺癌 广泛期 PFS 化疗 益气养阴 解毒 中药 免疫功能 |
| 英文关键词: small cell lung cancer extensive stage PFS chemotherapy enriching Qi and nourishing Yin detoxification traditional Chinese medicine immune function |
| 基金项目:上海市科学技术委员会医学引导项目(17401932400、19401930800)；上海市肺科医院学科骨干计划项目(fkgg1807)；国家自然科学基金青年基金项目(81207106) |
|
| 摘要点击次数: 1760 |
| 全文下载次数: 1476 |
| 中文摘要: |
| [目的]研究中药益气养阴解毒方对小细胞肺癌(small cell lung cancer，SCLC)患者一线化疗无进展生存期(progression-free survival，PFS)的影响。[方法]选择2014年9月1日至2019年6月30日就诊于同济大学附属上海市肺科医院中西医结合科的广泛期小细胞肺癌(extensive-stage small cell lung cancer，ES-SCLC)患者72例，将其中一线化疗有效的患者按疗效分为部分缓解(partial response，PR)、完全缓解(complete response，CR)和疾病稳定(stable disease，SD)三层，再分别将各层患者随机分为研究组(化疗+益气养阴解毒方口服)和对照组(单纯化疗)，研究组中药疗程至少半年，评价中药对患者PFS的影响。[结果]研究组中位PFS为(11.00±0.67)个月，对照组为(6.00±1.00)个月，研究组患者的PFS较对照组明显延长，差异有统计学意义(P=0.007)。两组间治疗前各指标比较，差异无统计学意义(P>0.05)，治疗后研究组与对照组比较，CD4+细胞明显升高，差异有统计学意义(P<0.05)。治疗前后比较，对照组患者化疗后免疫球蛋白M(immunoglobulin M，IgM)、转铁蛋白、CD4+细胞数、CD3+CD4+/CD3+明显下降，差异有统计学意义(P＜0.05)，但研究组却无明显下降，差异无统计学意义(P＞0.05)。[结论]固本与祛邪兼顾的益气养阴解毒方对于延长SCLC患者一线化疗后的PFS及总体生存期具有重要意义，而且能明显缓解化疗对患者免疫功能的影响。 |
| 英文摘要: |
| [Objective]To study the effect of traditional Chinese medicine(TCM) Yiqi Yangyin Jiedu formula on the progression-free survival(PFS) of the first-line chemotherapy in small cell lung cancer(SCLC) patients.[Methods]From September 1， 2014 to June 30， 2019， 72 patients with extensive-stage small cell lung cancer(ES-SCLC) treated in Department of Integrative Medicine， Shanghai Pulmonary Hospital were enrolled in this study. According to the response to the first-line chemotherapy， the patients were firstly stratified into three levels， partial response(PR)， complete response(CR) and stable disease(SD)， and then randomly divided into study group(chemotherapy+oral Yiqi Yangyin Jiedu formula) and control group(chemotherapy alone). The treatment course of TCM was at least half a year and the impact of this formula on PFS was evaluated.[Results]The median PFS of study group was(11.00±0.67) months， significantly longer than that of control group(6.00±1.00) months(P=0.007). The levels of immunoglobulin M(IgM)， CD4+， CD3+CD4+/CD3+ in control group declined significantly after treatment， and the difference was statistically significant before and after treatment(P＜0.05)， while there was no significant difference in study group before and after treatment(P＞ 0.05). [Conclusion]This study confirmed that Yiqi Yangyin Jiedu formula， which can strengthen the body and eliminate pathogenic factors， was of great significance in prolonging the PFS and the overall survival of first-line chemotherapy patients with SCLC， and alleviating the adverse effect of chemotherapy on immune function. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |