| 魏琦,李映霞,徐超,等.寒咳宁加味联合鼻腔冲洗治疗风寒恋肺型上气道咳嗽综合征的临床观察[J].浙江中医药大学学报,2021,45(3):265-269. |
| 寒咳宁加味联合鼻腔冲洗治疗风寒恋肺型上气道咳嗽综合征的临床观察 |
| Clinical Observation on Treatment of Upper Airway Cough Syndrome of Wind-cold Lingering in the Lung Type by Modified Hankening Combined with Nasal Irrigation |
| DOI：10.16466/j.issn1005-5509.2021.03.013 |
| 中文关键词: 上气道咳嗽综合征 寒咳宁加味 鼻腔冲洗 风寒恋肺型 生活质量 临床疗效 |
| 英文关键词: upper airway cough syndrome modified Hankening nasal irrigation wind-cold lingering in the lung type the quality of life clinical efficacy |
| 基金项目:江西省卫生计生委中医药科研基金项目(2018A077) |
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| 中文摘要: |
| [目的]观察寒咳宁加味联合鼻腔冲洗治疗风寒恋肺型上气道咳嗽综合征(upper airway cough syndrome，UACS)患者的临床疗效及对生活质量的影响。[方法]将90例符合纳入标准的UACS患者随机分为联合治疗组、中药组和对照组各30例。对照组予罗红霉素胶囊和氯雷他定片口服，中药组予寒咳宁加味，联合治疗组在中药组治疗基础上联合鼻腔冲洗，疗程均为2周。观察对比三组患者治疗前后临床疗效及莱赛斯特咳嗽量表(Leicester Cough Questionnaire，LCQ)评分的变化情况。三组患者治疗前后检测血常规、肝肾功能及心电图等，并观察可能出现的其他不良事件。[结果]联合治疗组临床疗效优于中药组和对照组，联合治疗组总有效率为93.3%，中药组总有效率为83.3%，对照组总有效率为80.0%。联合治疗组总有效率高于中药组与对照组，差异具有统计学意义(P＜0.05)。三组患者治疗后临床症状及LCQ评分均改善，与治疗前比较差异具有统计学意义(P＜0.05)。组间比较显示，联合治疗组在改善咳嗽、咳痰、鼻后滴漏感、鼻塞和(或)流涕、LCQ评分等方面均优于中药组和对照组(P＜0.05)，联合治疗组和中药组在改善咽痒和(或)咽部异物感方面优于对照组(P＜0.05)。三组患者治疗过程中均未发现不良反应。[结论]寒咳宁加味联合鼻腔冲洗可改善风寒恋肺型UACS患者临床症状，提高生活质量。 |
| 英文摘要: |
| [Objective]To observe the clinical effect of modified Hankening combined with nasal irrigation in the treatment of upper airway cough syndrome(UACS) and its influence on the quality of life. [Methods]Ninety patients with UACS who met inclusion criteria were randomly divided into combined treatment group， traditional Chinese medicine group and control group， with 30 cases in each group. Patients in control group were treated with Roxithromycin Capsules and Loratadine Tablets， patients in traditional Chinese medicine group were treated with modified Hankening， and combined treatment group was treated with nasal irrigation on the basis of traditional Chinese medicine group. The course of treatment in the three groups was 2 weeks. The clinical efficacy and changes of Leicester Cough Questionnaire(LCQ) score of the three groups were observed and compared before and after treatment. Blood routine， liver and kidney function and electrocardiographic(ECG) were accomplished before and after treatment， and other possible adverse events were observed. [Results] The clinical effect of combined treatment group was better than that of traditional Chinese medicine group and control group， total effective rate of 93.3% in combined treatment group， 83.3% in traditional Chinese medicine group， and 80.0% in control group. The total effective rate of combined treatment group was higher than that of traditional Chinese medicine group and control group， and the difference was significant(P＜0.05).The clinical symptoms and LCQ scores of the three groups were significantly improved after treatment(P＜0.05).Intergroup comparison showed that， the combined treatment group was superior to traditional Chinese medicine group and control group in relieving cough and expectoration， post-nasal leakage， nasal congestion and/or runny nose， LCQ score(P＜0.05). The combined treatment group and traditional Chinese medicine group were superior to control group in relieving pharyngeal itching and/or foreign body sensation(P＜0.05). No adverse reaction was found during the treatment in the three groups.[Conclusion]Modified Hankening combined with nasal irrigation can effectively relieve clinical symptoms and improve the quality of life of patients with UACS. |
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