文章摘要
黄丹,崔树娜.基于数据挖掘探析卵泡发育不良性不孕的中医临床用药规律[J].浙江中医药大学学报,2021,(3):300-305.
基于数据挖掘探析卵泡发育不良性不孕的中医临床用药规律
Exploring the Medication Rules of Follicular Maldevelopment Infertility Based on Data Mining
投稿时间:2020-06-15  
DOI:10.16466/j.issn1005-5509.2021.03.019
中文关键词: 卵泡发育不良  不孕  补益肝肾  滋阴  温阳  养精种玉汤  数据挖掘
英文关键词: follicular maldevelopment  infertility  tonifying the liver and kidney  nourishing Yin  warming Yang  Yangjing Zhongyu Decoction  data mining
基金项目:国家自然科学基金项目(81703969);江苏省自然科学基金项目(BK20160480);扬州市社会发展项目(YZ2017074);扬州大学研究生培养创新工程项目(XSJCX19_114)
作者单位E-mail
黄丹 扬州大学医学院 江苏扬州 225009  
崔树娜 扬州大学医学院 江苏扬州 225009 
扬州大学附属医院 
sncui@yzu.edu.cn 
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中文摘要:
      [目的]分析卵泡发育不良性不孕的中医用药规律,总结疾病特点和临床治疗思路,以期为中医药治疗本病提供借鉴。[方法]检索自建库起至2019年12月中国知网(China National Knowledge Infrastructure,CNKI)、万方数据库(WanFang Database)、维普中文科技期刊数据库(China Science and Technology Journal Database,VIP Database)等收录的中医药治疗卵泡发育不良性不孕症的临床研究及个人经验类文献,提取方药信息,基于“古今医案云平台V1.4”建立用药数据库进行频数分析,通过SPSS 23.0统计软件进行因子分析、聚类分析,运用Apriori 算法进行关联规则分析。[结果]筛选出的52篇文献中共有62首处方,涉及64味药,20类功效,共计362药物频次。频数分析显示,药物使用频率前6位的中药为菟丝子、山茱萸、当归、白芍、生地黄、熟地黄;药性多为平性、微寒性和温性,药味多为甘味、辛味和苦味,多归肝经、肾经、脾经、心经。关联规则分析显示关联性强的主要为养精种玉汤方中的子类药物组合,其他还有子类药与补阳药的配伍组合。高频药物聚类分析得到2个聚类方,两组药物均奏平补肝肾阴阳、养血调经之效,其中第一组药物偏重于滋阴辅阳以补肾阳、兼以养血,第二组药物偏重于滋肾阴、益肾精。[结论]临床上中医治疗卵泡发育不良性不孕用药以补益肝肾为主要治则,滋阴为主、温阳为辅,以平为期,调和阴阳。
英文摘要:
      [Objective] To analyse the medication rules of traditional Chinese medicine(TCM) for follicular maldevelopment(FM) infertility and summarize the disease characteristics and clinical treatment ideas, in order to provide instructions for the treatment of FM infertility with TCM. [Methods] The literature of clinical research and personal experience about treating FM infertility with TCM, published from the establishment of the database to December 2019, included in China National Knowledge Infrastructure(CNKI),WanFang Database and China Science and Technology Journal Database(VIP Database) were retrieved. The information of medical records was collected and extracted, and based on “Ancient and Modern Medical Records Cloud Computing Platform V1.4”, the medication database was established for frequency analysis. The factor analysis and cluster analysis were conducted by SPSS 23.0 statistical software, and the association rules were analyzed by using Apriori algorithm. [Results] There were 62 formulas, 64 drugs, 20 drug efficacy and 362 frequencies in 52 medical literatures. Frequency analysis showed that the top six types of frequently applied drugs were Cuscuta chinensis, Cornus officinalis, Angelicae sinensis, Cynanchum otophyllum, Rehmannia glutinosa, Radix Rehmanniae Preparata. The top three properties were mild, slightly cold and warm. The top three tastes were sweetness, acridity and bitterness, with sweetness as the dominance. The main meridian entries were liver, kidney, spleen and heart. The association rules analysis showed that subdrugs from the Yangjing Zhongyu Decoction were closely linked, and the subdrugs had close connection with warming Yang drugs. Two central drugs groups were obtained through clustering analysis, and both groups had the effect of tonifying Yin and Yang of the liver and kidney, nourishing blood and regulating menstruation. The first group of drugs focused on nourishing Yin and supplementing Yang to tonify the kidney Yang, and nourishing blood; the second group of drugs focused on nourishing the kidney Yin and tonifying the kidney essence. [Conclusion] Clinically, TCM treatment of FM infertility medication takes replenishing the liver and kidney as the main treatment principle, nourishing Yin as the main, warming Yang as the auxiliary, mildly regulating Yin and Yang.
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