| 郭海丽.黄芪桂枝五物汤熏洗联合艾灸治疗奥沙利铂所致恶性肿瘤患者周围神经毒性的临床疗效[J].浙江中医药大学学报,2021,45(5):521-525. |
| 黄芪桂枝五物汤熏洗联合艾灸治疗奥沙利铂所致恶性肿瘤患者周围神经毒性的临床疗效 |
| Clinical Effect of Huangqi Guizhi Wuwu Decoction Fumigation Combined with Moxibustion on Peripheral Neurotoxicity Induced by Oxaliplatin of Malignant Tumor Patients |
| DOI：10.16466/j.issn1005-5509.2021.05.016 |
| 中文关键词: 恶性肿瘤 周围神经毒性 黄芪桂枝五物汤 熏洗 艾灸 奥沙利铂 甲钴胺 中医护理 |
| 英文关键词: malignant tumor peripheral neurotoxicity Huangqi Guizhi Wuwu Decoction fumigation moxibustion oxaliplatin mecobalamin traditional Chinese medicine nursing |
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| 中文摘要: |
| [目的]探讨黄芪桂枝五物汤熏洗联合艾灸治疗奥沙利铂所致恶性肿瘤患者周围神经毒性的临床疗效。[方法]将100例符合纳入标准的患者随机分为A组、B组、C组和D组，每组各25例，A组采用甲钴胺治疗，B组在A组基础上联合艾灸治疗，C组在A组基础上联合黄芪桂枝五物汤熏洗治疗，D组为A组基础上联合艾灸及黄芪桂枝五物汤熏洗治疗。4个疗程结束后合格病例计100例，采用奥沙利铂Levi专用感觉神经毒性分级标准、欧洲癌症研究和治疗组织癌症患者生存质量测定量表评估疗效。[结果]与治疗前比较，四组患者治疗后神经毒性反应降低，差异均有统计学意义(P＜0.05)；A组、B组、C组、D组总有效率分别为56.0%、72.0%、76.0%、92.0%，D组有效率均优于其他三组，B组、C组优于A组，差异均有统计学意义(P＜0.05)；与其他三组比较，D组患者总体健康状况、躯体功能和情绪功能评分显著高于其他三组，差异具有统计学意义(P＜0.05)，A组、B组、C组间比较各有优劣，但差异无统计学意义(P＞0.05)。本研究过程中无任何明显不良事件的报告。[结论]在甲钴胺治疗的基础上，采用黄芪桂枝五物汤熏洗联合艾灸可以有效改善奥沙利铂所致周围神经毒性患者的躯体功能、情绪功能和社会功能，并能有效缓解疼痛，且较单独使用黄芪桂枝五物汤或艾灸或甲钴胺治疗效果更佳。 |
| 英文摘要: |
| [Objective]To observe the effect of Huangqi Guizhi Wuwu Decoction fumigation combined with moxibustion on peripheral neurotoxicity induced by oxaliplatin of malignant tumor patients. [Methods]One hundred participants were randomly divided into four groups， which were groups A， B， C and D， with 25 patients in each， respectively. Group A was treated with mecobalamin， group B was treated with moxibustion on the basis of group A， group C was treated with Huangqi Guizhi Wuwu Decoction fumigation on the basis of group A， and group D was treated with moxibustion and Huangqi Guizhi Wuwu Decoction fumigation on the basis of group A. There were 100 eligible cases after 4 courses of treatment; the efficacy was evaluated by oxaliplatin Levi sensory neurotoxicity rating scale and European Organization for Research and Treatment of Cancer Quality of Life Questionnare-Core 30 scale for cancer patients. [Results]Compared with those before treatment， the neurotoxic reactions of the four groups decreased after treatment(P＜0.05). The total effective rates of groups A， B， C and D were 56.0%， 72.0%， 76.0% and 92.0%， respectively. The effective rate of group D was better than those of the other three groups， and those of group B and group C were better than those of group A， with statistically significant differences(P＜0.05). Compared with the other three groups， the overall health status， physical function and emotional function scores of group D were significantly higher， with statistically significant differences(P＜0.05). There were advantages and disadvantages among group A， group B and group C， but the difference was not statistically significant(P＞0.05). No obvious adverse events were reported in the course of this study.[Conclusion]On the basis of mecobalamin treatment， Huangqi Guizhi Wuwu Decoction fumigation combined with moxibustion can effectively improve the physical function， emotional function and social function of patients with peripheral neurotoxicity induced by oxaliplatin， and effectively relieve pain， which is significantly better than the treatment of Huangqi Guizhi Wuwu decoction or moxibustion or mecobalamin alone. |
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