| 孙峰俐,虞芳,任志斌,等.二陈汤合桃红四物汤治疗非典型抗精神病药物所致痰瘀互结型代谢综合征的临床研究[J].浙江中医药大学学报,2021,45(6):612-617, 624. |
| 二陈汤合桃红四物汤治疗非典型抗精神病药物所致痰瘀互结型代谢综合征的临床研究 |
| A Placebo-controlled Study on the Treatment of Atypical Antipsychotic Drug Related Phlegm and Blood Stasis Type Metabolic Syndrome with Erchen Decoction and Taohong Siwu Decoction |
| DOI：10.16466/j.issn1005-5509.2021.06.008 |
| 中文关键词: 精神分裂症 代谢综合征 非典型抗精神病药物 二陈汤 桃红四物汤 痰瘀互结 精神症状 血脂 |
| 英文关键词: Schizophrenia metabolic syndrome atypical antipsychoticdrug Erchen decoction Taohong Siwu decoction phlegm and blood stasis mental symptom blood lipids |
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| 中文摘要: |
| [目的]观察二陈汤合桃红四物汤对非典型抗精神病药物所致痰瘀互结型代谢综合征以及精神症状的影响。[方法]选择2018年6月1日至2020年5月31日在浙江省精神卫生中心住院且符合精神分裂症、代谢综合征且中医辨证属于痰瘀互结证型的146例患者，按照2.1的比例随机分组，研究组98例予非典型抗精神病药物联合二陈汤合桃红四物汤加减治疗，对照组48例予非典型抗精神病药物联合中药安慰剂治疗，并分别于治疗前，治疗后1、2、3个月末评定阳性症状和阴性症状评定量表(positive and negative symptom scale，PANSS)、副作用反应量表(treatment emergent symptom scale，TESS)评分，并测量血压、体质量、腰围、臀围，检测空腹血糖、糖化血红蛋白、高密度脂蛋白、低密度脂蛋白、甘油三酯、总胆固醇水平。[结果]治疗前两组患者各生物学指标间差异均无统计学意义(P＞0.05)。与对照组比较，研究组治疗3个月后舒张压、腰围、糖化血红蛋白、总胆固醇、甘油三酯和低密度脂蛋白指标显著低于对照组，差异有统计学意义(P＜0.05)；其他指标治疗前后及组间比较，差异无统计学意义(P＞0.05)。与对照组比较，研究组治疗前PANSS、TESS评分差异无统计学意义(P＞0.05)，治疗3个月末普通症状显著降低，差异有统计学意义(P＜0.05)。[结论]二陈汤合桃红四物汤可以改善非典型抗精神病药物所致痰瘀互结型代谢综合征患者的舒张压、腰围、糖化血红蛋白、总胆固醇、甘油三酯和低密度脂蛋白指标，也可以改善这类患者情绪。 |
| 英文摘要: |
| [Objective] To observe the effects of Erchen decoction and Taohong Siwu decoction on phlegm blood stasis syndrome of metabolic syndrome related to atypical antipsychotic drug and mental symptoms. [Methods] One hundred and forty-six schizophrenic patients， who hospitalized in Zhejiang Mental Health Centre from Jun 1，2018 to May 31，2020 and met the all both diagnostic criteria of phlegm and blood stasis syndrome and metabolic syndrome were randomly divided into study and control groups according to the proportion of 2.1. The study group consisted of 98 patients treated by combination of atypical antipsychotic drug and Erchen decoction and Taohong Siwu decoction， while the control group consisted of 48 patients treated by atypical antipsychotic drug and traditional Chinese medicine(TCM) placebo. Positive and negative symptom scale(PANSS) and treatment emergent symptom scale(TESS) were assessed before treatment， at the end of the first， the second and third month after treatment. Blood pressure， weight， waist circumference， hip circumference， blood glucose， glycosylated hemoglobin， high-density lipoprotein， low-density lipoprotein， triglyceride and total cholesterol were also measured at same four time points. [Results]There was no statistic difference in all biological indexes between the two groups before treatment(P＞0.05). Compared with control group， the indexes of diastolic blood pressure， waist circumference， glycosylated hemoglobin， total cholesterol， triglyceride and low-density lipoprotein of study group after 3 months of treatment were significantly lower with statistic difference(P＜0.05). And there was no statistic difference in other biological indexes between two groups， before and after treatment(P＞0.05). Compared with control group， PANSS and TESS scores of study group had no statistic difference before treatment(P＞0.05)， and the general symptoms of study group were significantly lower than those of control group at the end of the third month of treatment(P＜0.05). [Conclusion] Erchen decoction and Taohong Siwu decoction are both beneficial to the treatment of diastolic blood pressure， waist circumference， glycosylated hemoglobin， total cholesterol， triglyceride and low density lipoprotein in metabolic syndrome of phlegm and blood stasis syndrome induced by atypical antipsychoticdrug， and to the improvement of such patients' emotion. |
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