| 杨柳青,陈菁双,章勤.何氏养巢方对高龄DOR不孕症患者卵巢功能及IVF结局的影响[J].浙江中医药大学学报,2021,45(10):1107-1112. |
| 何氏养巢方对高龄DOR不孕症患者卵巢功能及IVF结局的影响 |
| Effects of HE's Yangchao Formula on Ovarian Function and IVF Outcome in Elderly Patients with DOR Infertility |
| DOI：10.16466/j.issn1005-5509.2021.10.011 |
| 中文关键词: 卵巢储备功能减退 不孕症 诱导排卵 体外受精 何氏养巢方 临床疗效 高龄女性 何氏妇科 |
| 英文关键词: diminished ovarian reserve infertility ovulation induction in vitro fertilization HE's Yangchao Formula clinical efficacy elderly women HE's Gynecology |
| 基金项目:浙江省中医药重点研究项目(2017ZKL004)；浙江省中医药科技计划项目(2020ZA078)；浙江省中医药现代化专项项目(2021ZX012)；浙江省名老中医专家传承工作室建设项目(GZS2017014) |
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| 中文摘要: |
| [目的]观察何氏养巢方对肾虚型高龄卵巢储备功能减退(diminished ovarian reserve，DOR)不孕症患者卵巢功能及体外人工受精(in vitro fertilization，IVF)结局的影响。[方法]将符合纳入标准的患者随机分为对照组及治疗组各30例，治疗组予何氏养巢方预处理，对照组予脱氢表雄酮(dehydroepiandrosterone，DHEA)胶囊预处理，两组均采用高孕激素状态下促排卵方案(progestin primed ovarian stimulation，PPOS)进行IVF。预处理时间为3个月，观察治疗前后患者的肾虚证候评分、生殖激素水平，IVF周期中促性腺激素(gonadotropin，Gn)使用量及时间、获卵数、成熟卵率、受精数、受精率、卵裂胚胎数、卵裂率、可利用胚胎数、可利用胚胎率、优质胚胎数、优质胚胎率及周期取消率。[结果]何氏养巢方显著改善了高龄DOR不孕症患者的阴虚证候，其与DHEA均能提高血清抗苗勒管激素(anti-Müllerian hormone，AMH)水平，降低促卵泡生成素(follicle stimulating hormone，FSH)水平及促卵泡生成素/黄体生成素(follicle stimulating hormone/luteinizing hormone，FSH/LH)值；何氏养巢方降低FSH水平的效果优于DHEA(P＜0.05)。治疗组获卵数、成熟卵数、卵裂胚胎数、可利用胚胎数、优质胚胎数均显著优于对照组(P＜0.05)；除成熟卵率外，受精率、卵裂率、可利用胚胎率、优质胚胎率等参数组间比较差异无统计学意义(P＞0.05)。[结论]何氏养巢方改善了高龄DOR不孕症患者的卵巢功能、卵子质量以及IVF结局，且效果优于DHEA。 |
| 英文摘要: |
| [Objective] To observe the effect of HE's Yangchao Formula on the ovarian function and in vitro fertilization(IVF) outcome of elderly patients with kidney deficiency type diminished ovarian reserve(DOR) infertility. [Methods] Sixty patients were divided into treatment and control groups， with 30 cases in each group. Patients in treatment group were pretreated with HE's Yangchao Formula， and control group was pretreated with dehydroepiandrosterone(DHEA). Both groups were treated with a progestin primed ovarian stimulation(PPOS) program under progesterone state for IVF. The treatment cycle was three months， the scores of kidney deficiency syndromes and the levels of reproductive hormones before and after treatment were compared between the two groups. The total time and dosage of gonadotropin(Gn)， the number of oocytes obtained， the rate of mature oocytes， the number of fertilization and the rate of fertilization， the number of cleavage embryos and the rate of cleavage embryos， the number of available embryos and the rate of available embryos， the number of high-quality embryos and the rate of high-quality embryos， and cycle cancellation rate in the IVF cycle were compared between the two groups. [Results] HE's Yangchao Formula can significantly improve the kidney deficiency syndrome， it and DHEA can increase serum anti-Müllerian hormone(AMH) level and reduce follicle stimulating hormone(FSH) level and the value of follicle stimulating hormone/luteinizing hormone(FSH/LH). In lowering the level of FSH， the effect of HE's Yangchao Formula was better than that of DHEA(P＜0.05). The number of retrieved oocytes， mature oocytes， the number of cleavage embryos， available embryos， and high-quality embryos in treatment group were significantly higher than those in control group(P＜0.05). Except for the rate of mature oocytes， there was no significant difference in fertilization rate， the rate of cleavage embryos， available embryo rate and high-quality embryo rate between the two groups(P＞0.05). [Conclusion] HE's Yangchao Formula can improve the ovarian function of elderly patients with DOR infertility， the quality of oocytes and the outcome of IVF， and the clinical effect is better than DHEA. |
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