| 董群亚,吴琦琪,胡汉通,等.中药雾化吸入辅助治疗呼吸机相关性肺炎的Meta分析[J].浙江中医药大学学报,2021,45(12):1337-1342, 1357. |
| 中药雾化吸入辅助治疗呼吸机相关性肺炎的Meta分析 |
| Meta-analysis of Traditional Chinese Medicine Atomized Inhalation in Assisting Treatment of Ventilator-associated Pneumonia |
| DOI：10.16466/j.issn1005-5509.2021.12.014 |
| 中文关键词: 呼吸机相关性肺炎 中药 雾化吸入 随机对照试验 Meta分析 系统评价 |
| 英文关键词: ventilator-associated pneumonia traditional Chinese medicine atomized inhalation randomized controlled trial Meta-analysis system evaluation |
| 基金项目: |
|
| 摘要点击次数: 1213 |
| 全文下载次数: 966 |
| 中文摘要: |
| [目的] 系统评价中药雾化吸入辅助治疗呼吸机相关性肺炎的临床疗效及预后情况。[方法] 从建库到2021年4月，检索PubMed、Cochrane Library、Web of Science、 Clinical Trials、中国知网、维普、万方、中国生物医学文献数据库，纳入中药雾化吸入辅助治疗呼吸机相关性肺炎的随机对照试验，以临床总有效率、白细胞水平、降钙素原(procalcitonin，PCT)水平、重症监护室(intensive care unit，ICU)住院时间、氧合指数为结局指标，提取并合并数据。使用Cochrane协作网偏倚风险评估工具进行单个研究的质量评价，使用RevMan 5.4软件进行Meta分析。[结果] 最终纳入12篇文献，共计909例。Meta分析结果显示:中药雾化吸入组临床总有效率明显优于对照组[比值比(odds ratio，OR)=4.27，95%可信区间(confidence interval，CI)(2.53，7.20)，P＜0.00001]；中药雾化吸入可以降低白细胞水平[加权均数差(mean difference，MD)=-1.11，95%CI(-1.40，-0.81)，P＜0.00001]；降低PCT水平[MD=-0.49，95%CI(-0.59，-0.40)，P＜0.00001]；缩短ICU住院天数[MD=-2.70，95%CI(-3.13，-2.27)，P＜0.00001]；提高氧合指数[MD=52.07，95%CI(47.44，56.71)，P＜0.00001]。[结论] 中药雾化吸入辅助治疗呼吸机相关性肺炎可提高临床疗效并改善预后，但存在发表偏倚，需进一步验证。 |
| 英文摘要: |
| [Objective] To systematically evaluate the efficacy and prognosis of traditional Chinese medicine(TCM) atomized inhalation in assisting treatment of ventilator-associated pneumonia(VAP). [Methods] From construction to April 2021， PubMed， Cochrane Library， Web of Science， Clinical Trials， China National Knowledge Infrastructure(CNKI)， VIP， WanFang and SinoMed databases were searched for random controlled trials(RCTs) of TCM atomized inhalation in assisting treatment of VAP. The total effective rate， the level of white blood cell(WBC)， the level of procalcitonin(PCT)， the duration of intensive care unit(ICU) stay， and the oxygenation index of arterial oxygen pressure/inspired fraction of O2(PaO2/FiO2) were used as outcome indexes. The data were then extracted and merged. The bias risk assessment tool of Cochrane Collaboration was used to evaluate the quality of a single study. RevMan 5.4 software was used to conduct Meta-analysis. [Results] Twelve articles were included， 909 patients in total. Meta-analysis results showed that the total efficiency of TCM atomized inhalation group was significantly better than that of control group [odds ratio(OR)=4.27， 95% confidence interval(CI)(2.53，7.20)， P＜0.00001]. It had the lower level of WBC [mean difference(MD)=-1.11， 95%CI(-1.40，-0.81)，P＜0.00001]; and the lower level of PCT[MD=-0.49， 95%CI(-0.59，-0.40)， P＜0.00001]. TCM atomized inhalation could shorten the duration of ICU stay[MD=-2.70， 95%CI(-3.13，-2.27)， P＜0.00001]. It also had the higher oxygenation index of PaO2/FiO2[MD=52.07， 95%CI(47.44， 56.71)， P＜0.00001]. [Conclusion] The assisting treatment of VAP with TCM atomized inhalation can improve the clinical effect and prognosis. However， there is publication bias， which needs further verification. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |