| 刘玲,胡淼,顾佳麟,等.基于数据挖掘方法分析乳腺癌的中医证治规律[J].浙江中医药大学学报,2022,46(4):455-462, 467. |
| 基于数据挖掘方法分析乳腺癌的中医证治规律 |
| Analysis on Regularity of Prescriptions in Traditional Chinese Medicine Syndrome and Treatment of Breast Cancer Based on Data Mining |
| DOI：10.16466/j.issn1005-5509.2022.04.018 |
| 中文关键词: 乳腺癌 数据挖掘 中医药 证型 用药规律 气血两虚 |
| 英文关键词: breast cancer data mining traditional Chinese medicine type of syndrome medication rules both Qi and blood deficiency |
| 基金项目:江苏省科技项目(BE2019767) |
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| 摘要点击次数: 2665 |
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| 中文摘要: |
| [目的] 探讨乳腺癌的中医证型分布及用药规律。[方法] 检索2010年1月至2020年12月中国知识资源总库(China National Knowledge Infrastructure，CNKI)、万方数据学术论文总库(Wanfang Database)、维普中文科技期刊全文数据库(VIP Database for Chinese Technical Periodicals)中收录的、以中医药治疗乳腺癌的相关文献，并建立数据库，利用数据挖掘技术对其中的中药进行频次统计、药物功效分类及性味归经分析、关联规则分析和聚类分析。 [结果] 共纳入59篇文献，中医证型主要以气血两虚、气阴两虚、肝郁脾虚、肝郁气滞为主；单味中药使用频次位于前10位的分别是茯苓、白术、甘草、黄芪、白芍、当归、陈皮、熟地黄、柴胡、白花蛇舌草；使用频次较多的中药功效分类以补虚药和清热药为主，其次是利水渗湿药、活血化瘀药、理气药。中药性味以寒、温、甘、苦、辛为主，主入肝、脾、肾经。关联规则分析得出药对16对，聚类分析得到6类核心药物组合。[结论] 分析结果体现了现代中医辨治乳腺癌以虚证为主的证治特点，治疗以调补中焦脾胃为主，补益肝肾、疏肝养血，并配合化痰散结之法。 |
| 英文摘要: |
| [Objective] To explore the distribution of syndromes and medication rules of traditional Chinese medicine(TCM) in breast cancer. [Methods] China National Knowledge Infrastructure (CNKI) database， Wanfang Database and VIP Database for Chinese Technical Periodicals were used to search relevant literatures on the treatment of breast cancer of TCM from January 2010 to December 2020， a database was established， and the data mining technique was used to perform a statistical analysis of frequency， function of TCM herbs， and classification analysis of the nature， taste， and meridian tropism， association rule analysis and hierarchical cluster analysis. [Results] A total of 59 documents were included， the TCM syndromes were mainly both Qi and blood deficiency， both Qi and Yin deficiency， liver depression and spleen deficiency， liver depression and Qi stagnation. The top 10 most frequently used TCM herbs were Poria cocos， Atractylodes macrocephala， Glycyrrhiza uralensis， Astragalus membranaceus， Rasix paeoniae alba， Angelica sinensis， Pericarpium citrus reticulata， Radix rehmanniae praeparata， Bupleurum chinense， Hedyotis diffuse. The classification analysis of TCM function showed the most frequently used herbs were deficiency-tonifying herbs and heat-clearing herbs， followed by diuresis-inducing and dampness-draining herbs， blood circulation-activating and blood stasis-resolving herbs and Qi-regulating herbs. The analysis of the nature， taste and meridian tropism of TCM herbs showed that most of the commonly used herbs were cold， warm， sweet， bitter and pungent taste， and entered the liver， spleen， kidney meridians. The association rules yielded 16 pairs of drugs and the cluster analysis yielded 6 categories of coreherbs. [Conclusion] The analysis reflects the typical syndromes of breast cancer are based on deficiency syndrome in modern Chinese medicine， and the treatment is mainly achieved by tonifying middle-Jiao，tonifying the liver and kidney， soothing the liver and nourishing blood， and removing phlegm and dispersing knot. |
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