| 王雅琴,王真,钟佳燕,等.基于数据挖掘探讨王真教授治疗支气管哮喘的用药经验[J].浙江中医药大学学报,2022,46(8):872-877. |
| 基于数据挖掘探讨王真教授治疗支气管哮喘的用药经验 |
| Discussion on Professor WANG Zhen‘s Experience in Treating Bronchial Asthma Based on Data Mining |
| DOI：10.16466/j.issn1005-5509.2022.08.011 |
| 中文关键词: 数据挖掘 用药规律 支气管哮喘 清热解毒 辛开苦降 白芍 名医经验 |
| 英文关键词: data mining medication rules bronchial asthma clearing heat and removing toxin pungent dispersing and bitter descending Radix Paeoniae Alba famous doctor‘s experience |
| 基金项目:浙江省中医药科学研究基金项目(2021ZB124) |
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| 中文摘要: |
| [目的] 通过数据挖掘，归纳总结王真教授治疗支气管哮喘的临床经验。 [方法] 纳入王真教授2018年1月至2022年1月于浙江中医药大学附属第一医院湖滨院区门诊诊治的支气管哮喘278例，共1 348诊次，建立基础信息、四气五味、关联规则分析和聚类分析数据库，通过描述性频次分析、关联规则分析、聚类分析，研究其临床用药特点。 [结果] 共使用中药278味，累积用药频次81 536次，用药频次最多者为白芍。处方药物中，药性以温、寒、平、凉为多，药味以苦、辛、甘为多，归经以肺、脾、胃经为多，最常用的药物为清热解毒药、止咳化痰平喘药、补虚药。临床常用药对为枇杷叶、款冬花和紫菀，穿山龙、地龙和肺形草，桔梗、射干和麻黄，僵蚕、地龙和款冬花等。聚类分析提示高频中药可聚为3类，此时聚拢趋势较好，由此可知王真教授临证时以止嗽散合射干麻黄汤为基础，针对支气管哮喘急性发作和反复迁延的不同病理特点论治。[结论] 王真教授治疗支气管哮喘喜辛开苦降，以温为期，用药攻补兼施，既清热解毒，又健脾益气，临证时以止咳化痰平喘为治则，佐以化瘀、健脾、祛风，以止嗽散合射干麻黄汤为基础方，病证结合治疗。 |
| 英文摘要: |
| [Objective] To summarize the clinical experience of Professor WANG Zhen in the treatment of bronchial asthma. [Methods] Two hundred and seventy-eight cases of bronchial asthma diagnosed and treated by Professor WANG Zhen in the Hubin District of the First Affiliated Hospital of Zhejiang Chinese Medical University from January 2018 to January 2022， a total of 1 348 consultations were included. Databases of basic information，four properties and five flavors of herbs， association analysis and cluster analysis were established. The descriptive frequency analysis， association analysis and cluster analysis were used to study the clinical medication characteristics. [Results] A total of 278 herbs were used， and the medication frequency was 81 536. The most frequently used was Paeoniae Radix Alba. Among the prescription herbs， the properties were warm， cold， flat and cool and the flavors were bitter， pungent and sweet， and the meridians included lung， spleen and stomach meridians. The most commonly used herbs were heat-clearing and toxin-removing herbs， cough-reducing， phlegm-relieving and anti-asthmatic herbs， and tonic herbs. Commonly used herb pairs were Eriobotryae Folium， Tussilago farfara L. and Radix Asteris，Discorea nipponica Makino， Pheretimaas pergillum and Teucrium viscidum， Platycodonis Radix， Belamcanda chinensis and Ephedrasinica Sinica， Bombyx Batryticatus， Pheretimaas pergillum and Tussilago farfara L.， etc. Cluster analysis showed that high-frequency herbs can be clustered into three categories， and the clustering trend was better at this time. It can be seen that Professor WANG Zhen uses Zhisou Powder and Shegan Mahuang Decoction as the basis formulae for the different pathological characteristics of acute attacks and repeated prolongation of bronchial asthma. [Conclusion] Professor WANG Zhen treats bronchial asthma with pungent herbs to disperse and bitter herbs to descend， taking warmth as the purpose， and uses both herbs to attack and supplement， which can not only clear away heat and detoxify， but also strengthen the spleen and replenish Qi. The principle is relieving cough， resolving phlegm and relieving asthma， accompanied with removing blood stasis， strengthening the spleen and expelling wind. The prescription is based on Zhisou powder and Shegan Mahuang Decoction， combining with disease and syndrome. |
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