| WANG Yuxi,MENG Yilin,WANG Tong.基于复杂系统熵聚类分析《太平惠民和剂局方·治痰饮附咳嗽篇》的用药规律[J].浙江中医药大学学报,2022,46(8):913-919. |
| 基于复杂系统熵聚类分析《太平惠民和剂局方·治痰饮附咳嗽篇》的用药规律 |
| Based on the Complex System Entropy Clustering Analysis of Taiping Huimin Hejiju Fang·Treating Phlegm and Fluid with Cough Medication Rules |
| DOI：10.16466/j.issn1005-5509.2022.08.019 |
| 中文关键词: 太平惠民和剂局方 痰饮 高频药物 复杂系统熵聚类 四气 五味 归经 组方规律 |
| 英文关键词: Taiping Huimin Hejiju Fang phlegm and fluid high-frequency drug entropy clustering of complex systems four natures five flavors channel tropism prescription characteristics |
| 基金项目:中国社科院基金项目(20170908)；北京中医药大学中医学院重大传染病防治应急攻关项目(2020-YJGG-02) |
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| 中文摘要: |
| [目的] 挖掘《太平惠民和剂局方·治痰饮附咳嗽篇》的用药特点并分析潜在规律，进而指导痰饮病的临床用药。[方法]将《太平惠民和剂局方·治痰饮附咳嗽篇》的所有方剂录入Excel，统计方剂中单味药的频次、常用药对以及药物组合，采用关联规则分析、改进的互信息法、复杂系统熵聚类分析对药物关联规则及核心药物组合进行分析。[结果] 《太平惠民和剂局方·治痰饮附咳嗽篇》共包含方剂44首，涉及药物85味；使用频率最高的药物为半夏、人参、炙甘草、茯苓；最常见的药对:半夏和茯苓、半夏和陈皮、炙甘草和半夏；基于关联规则发现的常见药物组合:白术→炮姜(置信度0.83)、五味子→人参(置信度0.71)、桑白皮→人参(置信度0.71)；挖掘出核心组合2个，五味子、桑白皮、人参，半夏、炮姜、陈皮。[结论] 《太平惠民和剂局方·治痰饮附咳嗽篇》中常用药物和思路符合仲景治疗痰饮疾病的原则和用药思想，在此基础上重用化痰止咳药，重视调理肺腑，多用辛温药物发散行气、调畅气机，研究宋代医家对痰饮病的治疗思想，能够为现代临床治疗痰饮疾病提供新的诊疗思路。 |
| 英文摘要: |
| [Objective] To explore the medication characteristics and analyze the potential rule of Taiping Huimin Hejiju Fang·Treating Phlegm and Fluid with Cough， and guide the clinical medication of phlegm and fluid diseases. [Methods] All prescriptions in Taiping Huimin Hejiju Fang·Treating Phlegm and Fluid with Cough were recorded into Excel， and the frequency of single drug， common drug pairs and drug combinations in prescriptions were counted. Association rules analysis， improved mutual information method and complex system entropy clustering analysis were used to analyze drug association rules and core drug combinations. [Results] Taiping Huimin Hejiju Fang·Treating Phlegm and Fluid with Cough contained 44 prescriptions， involving 85 drugs. The most frequently used drugs were Pinellia ternata, Ginseng, Honey-fried licorice root and Poria cocos. The most common drug pairs: Pinellia ternata and Poria cocos, Pinellia ternata and Pericarpium citri reticulatae, Honey-fried licorice root and Pinellia ternate. Common drug combinations found based on association rules were: Large-headed atractylodes→Cannon ginger(confidence degree 0.83), Schisandra chinensis→Ginseng(confidence degree 0.71), The root bark of white mulberry→Ginseng(confidence degree 0.71). Two core combinations of excavation， Schisandra chinensis, The root bark of white mulberry and Ginseng， Ginseng，Large-headed atractylodes and Galangal were exhumed. [Conclusion] Taiping Huimin Hejiju Fang·Treating Phlegm and Fluid with Cough commonly used drugs and thinking in accordance with the ZHANG Zhongjing‘s thought and therapeutic principles of phlegm and fluid diseases， on the basis of reusing phlegm resolving and cough relieving drugs， attached importance to regulate the lung， and used more pungent and warm drugs to promote the circulation of Qi and regulate the Qi movement. Studying the treatment thought of doctors in Song Dynasty can provide new diagnosis and treatment ideas for modern clinical treatment of phlegm and fluid disease. |
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