| 彭红叶,吕文良,牛作虎,等.NAFLD患者CT值与舌象特征、实验室指标的关系研究[J].浙江中医药大学学报,2022,46(10):1116-1122, 1127. |
| NAFLD患者CT值与舌象特征、实验室指标的关系研究 |
| Study on the Relationship between CT Value and Tongue Features and Laboratory Indicators in Patients with |
| DOI：10.16466/j.issn1005-5509.2022.10.011 |
| 中文关键词: NAFLD CT值 舌象特征 血常规 肝功能 肾功能 血脂 相关性分析 |
| 英文关键词: NAFLD CT value tongue feature routine blood test liver function renal function blood fat correlation analysis |
| 基金项目: |
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| 摘要点击次数: 1503 |
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| 中文摘要: |
| [目的] 探究不同脂肪变性程度非酒精性脂肪性肝病(nonalcoholic fatty liver disease，NAFLD)患者的舌象特征及实验室指标差异。[方法] 2021年1月至2021年10月在中日友好医院体检中心招募NAFLD患者，根据肝脾计算机断层扫描(computed tomography，CT)比值结果分为轻中重三组，借助智能健康镜，采用统一标准化流程获取舌象信息。[结果] 共纳入NAFLD患者129例，轻度组83例、中度组34例、重度组12例，三组间性别、年龄差异无统计学意义(P＞0.05)，具有可比性。舌色比较:轻度组以淡红舌、红舌居多，中度组和重度组均以暗红舌居多，三组间舌色特征分布差异有统计学意义(P＜0.001)。苔色比较:重度组、中度组、轻度组黄苔检出率分别为91.7%、85.3%、62.7%，白苔检出率分别为8.3%、14.7%、37.3%，三组间苔色构成比差异有统计学意义(P＜0.05)。苔质比较:重度组厚苔检出率较中度组、轻度组有升高趋势(P＜0.05)。舌形比较:重度组、中度组、轻度组点刺舌检出率分别为66.7%、29.4%、28.9%，差异有统计学意义(P＜0.05)；瘀点舌检出率分别为100.0%、79.4%、38.6%，差异有统计学意义(P＜0.001)；瘀斑舌检出率分别为66.7%、41.2%、16.9%，差异有统计学意义(P＜0.001)。重度组丙氨酸氨基转移酶(alanine aminotransferase，ALT)和尿酸(uric acid，UA)水平显著高于轻度组(P＜0.05)。肝脏CT值、肝脾CT比值均与ALT、天门冬氨酸氨基转移酶(aspartate aminotransferase，AST)、UA呈负相关。[结论] 热邪、痰湿和血瘀等致病因素与NAFLD患者脂肪变性程度密切相关，脂肪变性程度与肝酶和UA水平存在相关性。 |
| 英文摘要: |
| [Objective] To explore the difference of tongue features and laboratory indicators in nonalcoholic fatty liver disease(NAFLD) patients with different degrees of steatosis. [Methods] From January 2021 to October 2021， NAFLD patients were recruited in the physical examination center of China-Japan Friendship Hospital. According to the liver-spleen computed tomography(CT) ratio results， they were divided into mild group， moderate group and severe group. Tongue image information was obtained by using intelligent health goggles and standardized procedures. [Results] A total of 129 NAFLD patients were enrolled， including 83 in mild group， 34 in moderate group， and 12 in severe group. There were no significant differences in gender and age among the three groups(P＞0.05) with comparability. Comparison of tongue colors: Light red tongue and red tongue were predominant in mild group， and dark red tongue was predominant in moderate group and severe group. The characteristic distribution of tongue color was statistically different among the three groups(P＜0.001). Comparison of moss colors: The detection rates of yellow moss in severe group， moderate group and mild group were 91.7%， 85.3%， 62.7% respectively， and the detection rates of white moss in moderate group were 8.3%， 14.7%， 37.3% respectively(P＜0.05). The detection rate of thick moss in severe group was higher than that in three groups and mild group(P＜0.05). Tongue shape comparison: The detection rates of tongue prick in severe group， moderate group and mild group were 66.7%， 29.4% and 28.9% respectively， with significant difference(P＜0.05); the positive rates of petechiae tongue in the three groups were 100.0%， 79.4% and 38.6% respectively(P＜0.001); the positive rates of ecchymosis tongue in the three groups were 66.7%， 41.2% and 16.9% respectively(P＜0.001). Alanine aminotransferase(ALT) and uric acid(UA) levels in severe group were significantly higher than those in mild group(P＜0.05). CT value of liver and CT ratio of liver and spleen were negatively correlated with ALT， aspartate aminotransferase(AST) and UA. [Conclusion] Pathogenic factors such as heat evil， phlegm dampness and blood stasis were closely related to the degree of steatosis in NAFLD patients， and the degree of steatosis was correlated with liver enzymes and UA levels. |
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