| 魏蜀吴,孙卫卫,姜伟民,等.痰湿与2型糖尿病脂代谢紊乱的相关性临床研究[J].浙江中医药大学学报,2022,46(10):1136-1140. |
| 痰湿与2型糖尿病脂代谢紊乱的相关性临床研究 |
| Research on the Correlation of Phlegm-dampness Syndrome and Type 2 Diabetes Mellitus with Dyslipidemia |
| DOI：10.16466/j.issn1005-5509.2022.10.015 |
| 中文关键词: 2型糖尿病 痰湿证 总胆固醇 甘油三酯 低密度脂蛋白胆固醇 高密度脂蛋白胆固醇 肾功能损伤 中医药 |
| 英文关键词: type 2 diabetes mellitus phlegm-dampness syndrome total cholesterol triglyceride low density lipoprotein-cholesterol high density lipoprotein-cholesterol renal function injury traditional Chinese medicine |
| 基金项目:国家中医药管理局科研基金项目(201207012) |
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| 中文摘要: |
| [目的] 探讨痰湿与2型糖尿病(type 2 diabetes mellitus，T2DM)脂代谢紊乱的相关性。[方法] 收集833例T2DM患者的临床资料，分析比较痰湿证与非痰湿证患者的肾功能指标与总胆固醇(total cholesterol，TC)、甘油三酯(triglyceride，TG)、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol，LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol，HDL-C)水平，并探究T2DM患者血脂水平与肾功能指标及痰湿程度的相关性。[结果] 与非痰湿证患者比较，痰湿证患者尿素氮、血肌酐、尿酸水平均升高(P＜0.01)，估算肾小球滤过率(estimated glomerular filtration rate，eGFR)降低(P＜0.01)；TC、TG、LDL-C水平升高(P＜0.01)，HDL-C水平降低(P＜0.05)。TC与尿素氮呈正相关，与eGFR呈负相关；TG与血肌酐、尿酸呈正相关，与eGFR呈负相关；LDL-C与尿素氮、血肌酐呈正相关，与eGFR呈负相关；HDL-C与血肌酐、尿酸呈负相关；痰湿证与TC、LDL-C呈正相关，随痰湿程度加重，其相关系数增加，轻度痰湿证与HDL-C呈负相关。[结论] T2DM痰湿证患者脂代谢紊乱程度更严重，肾功能更差。痰湿证是血脂水平发生异常的危险因素之一，脂代谢紊乱与T2DM早期肾功能损伤密切相关。本研究为从痰湿纠正T2DM脂代谢异常、延缓肾脏损伤提供了新思路。 |
| 英文摘要: |
| [Objective] To explore the correlation of phlegm-dampness syndrome and type 2 diabetes mellitus(T2DM) with dyslipidemia. [Methods] It collected clinical data of 833 patients with T2DM， compared the renal function indexes and total cholesterol(TC)， triglyceride(TG)， low density lipoprotein-cholesterol(LDL-C)， high density lipoprotein-cholesterol(HDL-C) levels of the patients with and without phlegm-dampness syndrome. [Results] Compared with non-phlegm-dampness patients， the levels of urea nitrogen， serum creatinine and uric acid were higher(P＜0.01)， and the levels of estimated glomerular filtration rate(eGFR) were lower(P＜0.01)； and the levels of TC，TG，LDL-C were higher(P＜0.01)， HDL-C levels were lower(P＜0.05) in phlegm-dampness patients. TC levels were positively correlated with urea nitrogen， and negatively correlated with eGFR； TG levels were positively correlated with serum creatinine and uric acid， and negatively correlated with eGFR； LDL-C levels were positively correlated with urea nitrogen and serum creatinine， and negatively correlated with eGFR； HDL-C levels were negatively correlated with uric acid and serum creatinine. The phlegm-dampness syndrome was positively correlated with TC and LDL-C， and with the increase of phlegm-dampness degree， the risk of TC and LDL-C increased gradually； HDL-C levels were negatively correlated with mild phlegm-dampness syndrome. [Conclusion] T2DM patients with phlegm-dampness syndrome had worse renal function and higher levels of dyslipidemia. Phlegm-dampness syndrome was one of the risk factors for the dyslipidemia， and dyslipidemia was closely related to early renal function injury. This research provides evidence for the treatment of T2DM from phlegm-dampness in clinic. |
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