| 张再阳,闫鑫,张翼宙.大补阴丸加减治疗阴虚型围绝经期综合征的临床研究[J].浙江中医药大学学报,2022,46(12):1363-1366. |
| 大补阴丸加减治疗阴虚型围绝经期综合征的临床研究 |
| Clinical Study on the Treatment of Perimenopausal Syndrome of Yin Deficiency Type with Modified Dabuyin Pill |
| DOI：10.16466/j.issn1005-5509.2022.12.012 |
| 中文关键词: 大补阴丸 阴虚型 围绝经期综合征 临床研究 疗程 改良Kupperman指数积分 中医症状积分 浙派中医 |
| 英文关键词: Dabuyin Pill Yin deficiency type perimenopausal syndrome clinical study course of treatment modified Kupperman index scores traditional Chinese medicine symptom scores Zhejiang traditional Chinese medicine school |
| 基金项目:浙江省中医药科学研究基金项目(2018ZA030) |
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| 中文摘要: |
| [目的] 探讨大补阴丸加减治疗阴虚型围绝经期综合征的临床疗效，以及疗程与症状的关系。[方法] 对资料完整的60例患者进行回顾性研究，按照疗程2个月和3个月分为两组，每组各30例，观察两组患者的有效率、改良Kupperman指数(Kupperman index，KI)积分和中医症状积分。[结果] 疗程2个月组的有效率为83.33%，疗程3个月组的有效率为93.33%，组间比较差异无统计学意义(P＞0.05)。两组患者改良KI积分和中医症状积分治疗后较治疗前明显降低，差异有统计学意义(P＜0.05)。治疗前疗程3个月组患者的改良KI积分和中医症状积分高于疗程2个月组，差异有统计学意义(P＜0.05)；治疗后两组患者的改良KI积分和中医症状积分差异无统计学意义(P＞0.05)。两组患者的5个中医症状积分治疗后较治疗前明显降低，差异有统计学意义(P＜0.05)。治疗前疗程3个月组患者烘热汗出、五心烦热、烦躁易怒、口干便秘等症状积分高于疗程2个月组，差异有统计学意义(P＜0.05)，而失眠多梦症状的积分与疗程2个月组比较，差异无统计学意义(P＞0.05)。[结论] 烘热汗出、五心烦热、烦躁易怒、口干便秘等是阴虚型围绝经期综合征的典型症状。大补阴丸加减治疗阴虚型围绝经期综合征有较好的疗效，其疗程与症状轻重有关，症状重者需加长疗程。 |
| 英文摘要: |
| [Objective] To investigate the clinical effect of modified Dabuyin Pill in the treatment of perimenopausal syndrome of Yin deficiency type， and the relationship between the course of treatment and symptoms. [Methods] A retrospective study was carried out on 60 patients with complete data. According to the 2-month and 3-month courses of treatment， they were divided into two groups with 30 cases in each group. The effective rate， modified Kupperman index(KI) scores and traditional Chinese medicine(TCM) symptom scores were observed in the two groups. [Results] The effective rate was 83.33% in 2-month treatment(M2) group and 93.33% in 3-month treatment(M3) group， and there was no significant difference between the two groups(P＞0.05). After treatment， the modified KI scores and TCM symptom scores of the two groups were significantly lower than those before treatment， and the difference was statistically significant(P＜0.05). Before treatment， the modified KI scores and TCM symptom scores of patients in M3 group were higher than those in M2 group， and the difference was statistically significant(P＜0.05). After treatment， there was no significant difference in the modified KI scores and TCM symptom scores between the two groups(P＞0.05). The five TCM symptom scores of the two groups of patients after treatment were significantly lower than those before treatment， and the difference was statistically significant(P＜0.05). The TCM symptom scores of the patients in M3 group were higher than those in M2 group， such as tidal fever and sweating， vexing heart in chest， palms and soles， feelings of vexation， dry mouth and constipation， and the difference was statistically significant(P＜0.05)； however， there was no significant difference in the TCM symptom scores of insomnia and dreaminess compared with M2 treatment group(P＞0.05). [Conclusion] Tidal fever and sweating， vexing heart in chest， palms and soles， feelings of vexation， dry mouth and constipation are typical symptoms of Yin deficiency type perimenopausal syndrome. Modified Dabuyin Pill has good curative effect in the treatment of perimenopausal syndrome of Yin deficiency type. The course of treatment is related to the severity of symptoms， and patients with severe symptoms need to prolong the course of treatment. |
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