| 史华洁,蒋越,赵东瑞,等.基于数据挖掘分析曹毅教授治疗慢性荨麻疹的用药规律[J].浙江中医药大学学报,2022,46(12):1367-1373. |
| 基于数据挖掘分析曹毅教授治疗慢性荨麻疹的用药规律 |
| Analysis of the Medication Regularity of Professor CAO Yi in the Treatment of Chronic Urticaria Based on Data Mining |
| DOI：10.16466/j.issn1005-5509.2022.12.013 |
| 中文关键词: 慢性荨麻疹 数据挖掘 用药规律 聚类分析 学术经验 名老中医 曹毅 |
| 英文关键词: chronic urticaria data mining medication regularity cluster analysis academic experience famous traditional Chinese medical doctor CAO Yi |
| 基金项目:浙江省名老中医专家传承工作室曹毅名老中医专家传承工作室(GZS2020022) |
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| 中文摘要: |
| [目的] 通过分析曹毅教授治疗慢性荨麻疹患者的中药处方，总结曹教授治疗慢性荨麻疹的组方用药规律。 [方法] 基于门诊病历系统，收集并筛选浙江省中医院曹毅教授2021年1月1日至2021年12月31日诊治的慢性荨麻疹患者的处方，由双人审核后建立数据库。运用中医传承计算平台V3.0、SPSS Statistics 25.0统计软件及SPSS Modeler 18.0数据挖掘软件，对中药数据进行频次统计、药物聚类及关联规则分析。 [结果] 共纳入处方142例，药物174味，总计频次2 078次。其中用药频次最高的前5味中药依次为白鲜皮(80.99%)、牡丹皮(79.58%)、当归(71.83%)、甘草(67.61%)、桂枝(61.97%)，药物以清热药为主，其次为补虚药。药性多为寒性和温性，药味以甘、苦并用，归经以肝、脾、心经为主。在支持度为50%的情况下，药物组合频次最高的是牡丹皮和白鲜皮，其置信度为0.88。基于季节的用药分析中，春夏季节与秋冬季节部分药物的使用频率存在差异。 [结论] 曹教授治疗慢性荨麻疹注重寒热并用，共奏清热祛风、益气养血之效。 |
| 英文摘要: |
| [Objective] To summarize the medication regularity of Professor CAO Yi in the treatment of chronic urticarial， through analyzing Professor CAO‘s prescription of traditional Chinese medicine(TCM) in the treatment of patients with chronic urticaria. [Methods] Based on the outpatient medical record system， the prescriptions of chronic urticaria diagnosed and treated by Professor CAO of Zhejiang Hospital of Traditional Chinese Medicine from January 1， 2021 to December 31， 2021 were collected and selected， and the database was established after double examination. The Traditional Chinese Medicine Inheritance Computing Platform V3.0， SPSS Statistics 25.0 software and Modeler 18.0 data mining software was used to analyze the frequency statistics， drug clustering and association rules of drugs. [Results] A total of 142 prescriptions containing 174 drugs were included， with a total frequency of 2 078. Among them， the top five drugs with the highest frequency were Cortex Dictamni(Baixianpi， 80.99%)， Moutan Cortex(Mudanpi， 79.58%)， Angelica Sinensis(Danggui， 71.83%)， Glycyrrhiza uralensis(Gancao， 67.61%) and Ramulus Cinnamomi(Guizhi， 61.97%)； also， the TCM incorporated is mainly heat-clearing drugs， followed by tonifying deficiency drugs. The medicinal properties are mostly cold and warm， and the taste of medicine is sweet and bitter， and the meridians are mainly liver， spleen and heart meridian. In the case of 50% support， the highest frequency of drug combination is Moutan Cortex and Cortex Dictamni， whose confidence is 0.88. In the season-based drug use analysis， there are differences in the frequency of some drugs between spring and summer & autumn and winter. [Conclusion] Professor CAO pays attention to the combination of cold and heat in the treatment of chronic urticaria， and plays the effect of clearing heat and dispelling wind， replenishing Qi and nourishing blood. |
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