| 旦增巴珍,次旺欧珠,张瑜,等.含佐太藏药复方制剂的研究[J].浙江中医药大学学报,2022,46(12):1412-1416, 1420. |
| 含佐太藏药复方制剂的研究 |
| The Research on Tibet Medicine Compound Preparations Containing Zuotai |
| DOI：10.16466/j.issn1005-5509.2022.12.020 |
| 中文关键词: 国药准字 佐太 复方制剂 炮制 佐辅剂 重金属 水银洗炼法 蓄积 |
| 英文关键词: National Medical Products Administration Approval Zuotai compound preparations processed adjuvant heavy metal mercury washing method accumulation |
| 基金项目:浙江中医药大学学生发展性资助项目(S202110344008X) |
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| 中文摘要: |
| [目的] 探讨6种国药准字含佐太藏药复方制剂的药理作用以及相关安全性问题。[方法] 以佐太及各复方制剂的中英文为 |
| 英文摘要: |
| [Objective] To discuss the pharmacological mechanism and the medication safety of six National Medical Products Administration(NMPA) Approval Tibet medicines containing Zuotai. [Methods] By searching China National Knowledge Infrastructure(CNKI)， China Science and Technology Journal Database(VIP)， Wanfang， Web of Science， PubMed and Science Direct database(up to now) with Zuotai and compound preparations in Chinese and English as Keywords， all the literature of Zuotai and compound preparations was retrieved. The mechanism and toxicity status of Tibet medicine containing Zuotai was summarized according to historical Tibetan medical books and contemporary academic papers. [Results] Zuotai is made of eight gold， eight minerals and many natural herbs， more than 100 formulas of Zuotai are recorded in the Classical Book of Tibetan Medicine Rgyud bzhi. Zuotai is an adjuvant with other herb medicines to improve the curative effect and reduce toxicity. Compound preparations of Tibet medicine containing Zuotai could improve the function of central nervous system and digestive system， regularize the intestinal micro-ecology and nonspecific immunity， and auxiliary treatment of cancer. Zuotai contains heavy metals， but is processed by the technology of mercury washing method， the heavy metals in Zuotai losting its toxicity nearly， so these compound preparations containing Zuotai are safe and without obvious acute and longtime toxicity in reasonable clinical dosage. The compound preparations containing Zuotai will produce some mercury accumulation in the liver and kidney in medication period， but mercury will be gradually excreted after withdrawal， so the accumulation of mercury in the liver and kidney is reversible. [Conclusion] Zuotai is an indispensable component in precious Tibet medicine. The pharmaceutical value of Zuotai in Tibet medicine compound preparations should be explained in a variety of ways， such as the modern medical views of raw and auxiliary materials， processing technology， pharmacology， toxicology and clinical evaluation. |
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