文章摘要
郭雯,郭建辉,邢雅娟,等.活络效灵丹加味方治疗血瘀型银屑病的效果及对血液流变学和血浆内皮素的影响[J].浙江中医药大学学报,2023,47(2):184-189.
活络效灵丹加味方治疗血瘀型银屑病的效果及对血液流变学和血浆内皮素的影响
Effect of Revised Huoluo Xiaoling Pill on Blood Stasis Psoriasis and Its Effect on Hemorheology and Plasma Endothelin Level
DOI:10.16466/j.issn1005-5509.2023.02.014
中文关键词: 活络效灵丹  银屑病  血浆内皮素  血液流变学  中医证候  皮损面积  炎症反应
英文关键词: Reried Hoo Xialing nlan ammation response to enhance the ,herapeutie efect.tory response Pll  psoriasis  plasma endothelin  hemorheology  TCM syndrome  skin lesion area  inlamma-tory response
基金项目:河北省中医药管理局科技计划项目(2020461)
作者单位
郭雯 沧州中西医结合医院 河北沧州 061001 
郭建辉 沧州中西医结合医院 河北沧州 061001 
邢雅娟 沧州中西医结合医院 河北沧州 061001 
朱丽 沧州中西医结合医院 河北沧州 061001 
杨晓春 沧州中西医结合医院 河北沧州 061001 
王芳 沧州中西医结合医院 河北沧州 061001 
李梦丽 沧州中西医结合医院 河北沧州 061001 
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中文摘要:
      [目的] 观察活络效灵丹加味方治疗血瘀型银屑病的效果及对血液流变学和血浆内皮素水平的影响。 [方法] 选取沧州中西医结合医院2019年1月至2021年8月接收的102例血瘀型银屑病患者,采用随机数字表法分为两组,对照组51例给予迪银片治疗;治疗组51例实施活络效灵丹加味方治疗。观察两组中医证候(主症包括皮损肥厚、颜色暗红、干燥鳞屑,次症包括瘙痒、口干、舌苔暗紫、脉涩细缓),血液流变学(血浆黏度、全血黏度低切、全血黏度高切、血沉、红细胞压积)指标水平,皮损面积及严重程度,炎性因子表达及疗效情况。 [结果] 两组治疗前中医证候积分对比差异无统计学意义(P>0.05),治疗后治疗组皮损肥厚、颜色暗红、干燥鳞屑、瘙痒、口干、舌苔暗紫、脉涩细缓证候积分均低于对照组(P<0.01)。两组治疗前血液流变学指标水平对比差异无统计学意义(P>0.05),治疗后治疗组血浆黏度、全血黏度低切、全血黏度高切、血沉、红细胞压积水平均低于对照组(P<0.01)。两组治疗前损面积及皮损红斑、浸润、脱屑严重程度评分对比差异无统计学意义(P>0.05),治疗后治疗组皮损面积及皮损红斑、浸润、脱屑严重程度评分低于对照组(P<0.01)。两组治疗前炎性因子表达对比差异无统计学意义(P>0.05),治疗后治疗组白细胞介素-17(interleukin-17,IL-17)和白细胞介素-23(interleukin-23,IL-23)水平低于对照组(P<0.01)。治疗组总有效率(96.08%)高于对照组(76.47%),差异有统计学意义(P<0.01)。 [结论] 活络效灵丹加味方治疗血瘀型银屑病能显著改善患者血液流变学指标和中医证候,同时减轻患者皮损,缓解炎症反应,提升治疗效果。
英文摘要:
      [Objective] To analyze the effect of Revised Huoluo Xiaoling Pill on blood stasis psoriasis and its effect on hemorheology and plasma endothelin level. [Methods] One hundred and two patients with blood stasis psoriasis received in Cangzhou Integrated Traditional Chinese and Western Medicine Hospital from January 2019 to August 2021 were selected and divided into two groups by random number table method. The 51 cases in control group were treated with Diyin tablets; the other 51 cases in treatment group were treated with Revised Huoluo Xiaoling Pill. Traditional Chinese medicine(TCM) syndromes main symptoms including hypertrophic skin lesions, dark red color, dry scales, secondary symptoms include itching, dry mouth, dark purple tongue coating and astringent pulse, hemorheology index including plasma viscosity, whole blood viscosity low shear, whole blood viscosity high shear, erythrocyte sedimentation rate(ESR), hematocrit, skin lesion area and severity of skin lesions, inflammatory factor expression, and therapeutic efficacy of the two groups were observed. [Results] There was no difference in TCM syndrome scores between the two groups before treatment(P>0.05); after treatment, the scores of hypertrophic skin lesions, dark red color, dry scales, itching, dry mouth, dark purple tongue coating and astringent pulse in treatment group were lower than those in control group(P<0.01). There was no difference in the levels of hemorheological indexes between the two groups before treatment(P>0.05); after treatment, the plasma viscosity, whole blood viscosity low shear, whole blood viscosity high shear, ESR and hematocrit levels in treatment group were lower than those in control group(P<0.01). There was no difference in the skin lesion area and the severity, erythema, infiltration and desquamation scores between the two groups(P>0.05); after treatment, the scores of skin lesion area, erythema, infiltration and desquamation severity in the treatment group were lower than those in the control group(P<0.01). There was no difer crence in the the lelsof ierleukir 1 101-11 andin xpesion of in mmatoy fctors between two groups before tatmen(P>O.05);afer treatment,ment g0up06 08%) was higher vsedHuouo Xialing Pll in the than that in control group(76.47%),the diferer n contol group(P<0.01). The lotal efective rale in treat-tiens, reduce the skin lesions, and rlieve inan ; treatment of boods stasis psoriasis can snigicanly, impove the ; henorheology and TCM syndromes f pa-K
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