| 徐新宇,殷一红,崔云,等.从“脾虚湿瘀”论免疫性不育病机及治疗[J].浙江中医药大学学报,2023,47(4):443-449. |
| 从“脾虚湿瘀”论免疫性不育病机及治疗 |
| Discuss the Pathogenesis and Treatment of Immune Infertility From “Dampness-Blood Stasis Induced by Spleen Deficiency” |
| DOI：10.16466/j.issn1005-5509.2023.04.020 |
| 中文关键词: 免疫性不育 脾虚湿瘀 抗精子抗体 中虚精变 当归芍药散 病机 |
| 英文关键词: immune infertility dampness-blood stasis induced by spleen deficiency anti-sperm antibody semen changes due to middle deficiency Danggui Shaoyao Powder pathogenesis |
| 基金项目:全国名老中医药专家传承工作室建设项目(国中医药人教函﹝2022﹞75号)；浙江省中医药科技计划项目(2023ZF041、2023ZF042、2023ZF161)；宁波市中医医学重点学科建设计划(2022-Z04、2022-Z05) |
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| 中文摘要: |
| [目的] 运用中虚精变理论的“脾虚湿瘀”观点，对男性免疫性不育的病机和治疗进行阐发。[方法] 从中虚精变理论“脾虚湿瘀”观点及免疫性不育病因病机出发，探讨二者的理论契合性，并基于“脾虚湿瘀”观点，确立免疫性不育的论治原则及代表方药。[结果] “脾虚湿瘀”观点植根于中虚精变理论，以脾虚为本、湿瘀为标，重视阐发理论的中虚致实部分。免疫性不育病机特点在于本虚标实，本虚主要是脾虚、肝肾亏虚，在虚的基础上化生或合并湿、热、瘀等实邪。从“脾虚湿瘀”分析免疫性不育病机，虚证论治不仅要重视脾虚，亦当兼顾肝肾，实证论治不仅要重视湿瘀，亦须重视热、痰、浊、毒之衍变，这些因素均与免疫性不育的产生密切相关。以“脾虚湿瘀”指导免疫性不育的治疗，要以健脾活血祛湿为要，以当归芍药散为代表方，并注重化裁，其运用的合理性已获得临床研究的支持。[结论] “脾虚湿瘀”观点与免疫性不育病机具有契合性，为本病的临床治疗开辟了新思路。 |
| 英文摘要: |
| [Objective] To elucidate the pathogenesis and treatment of male immune infertility based on the viewpoint of “dampness-blood stasis induced by spleen deficiency” of the theory of semen changes due to middle deficiency. [Methods] Based on the viewpoint of “dampness-blood stasis induced by spleen deficiency” of the theory of semen changes due to middle deficiency and the etiology and pathogenesis of immune infertility， this paper discussed the theoretical compatibility between them， and established the treatment principles and representative formulas of immune infertility based on the viewpoint of“dampness-blood stasis induced by spleen deficiency”. [Results] The viewpoint of “dampness-blood stasis induced by spleen deficiency” is rooted in the theory of semen changes due to middle deficiency， taking spleen deficiency as the foundation and dampness and stasis as the symptoms， and paying attention to expounding the part of the theory of middle deficiency causing excess. The pathogenesis of immune infertility is characterized by the deficiency of foundation and the excess of symptoms， the deficiency of foundation mainly the deficiency of the spleen and the deficiency of the liver and kidney. On the basis of the deficiency， the deficiency is generated or combined with dampness， heat， blood stasis and other excess evils. To analyze the pathogenesis of immune infertility from “dampness-blood stasis induced by spleen deficiency”， the diagnosis and treatment of deficiency syndrome should pay attention not only to deficiency of the spleen， but also to the liver and kidney， and the diagnosis and treatment of excess syndrome should pay attention not only to dampness and stasis， but also to the evolution of heat， phlegm， turbidity and poison， which are closely related to the generation of immune infertility. To guide the treatment of immune infertility with “dampness-blood stasis induced by spleen deficiency” should take invigorating the spleen and activating blood circulation and dispelling dampness as the key， take Danggui Shaoyao Powder as the representative prescription， and pay attention to modify drugs according to the syndrome， and the rationality of application has been supported by clinical studies. [Conclusion] The viewpoint of “dampness-blood stasis induced by spleen deficiency” is consistent with the pathogenesis of immune infertility， which opens up a new idea for the clinical treatment of this disease. |
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