| 陈玥,佘婧瑶,王静,等.基于数据挖掘的中医平衡理论与早发性卵巢功能不全用药关联性初探[J].浙江中医药大学学报,2023,47(5):524-531. |
| 基于数据挖掘的中医平衡理论与早发性卵巢功能不全用药关联性初探 |
| Discussion of the Balance Theory of Traditional Chinese Medicine Association with Medication in Premature Ovarian Insufficiency Based on Data Mining |
| DOI：10.16466/j.issn1005-5509.2023.05.014 |
| 中文关键词: 早发性卵巢功能不全 中医药 平衡理论 配伍规律 核心处方 数据挖掘 中医传承辅助平台 |
| 英文关键词: premature ovarian insufficiency traditional Chinese medicine balance theory compaibility rules core precription data mining Traditional Chinese Medicine Inheritance Assist System |
| 基金项目:国家自然科学基金项目(81903998、81904245、82074487)；中国中西医结合妇产科专项研究基金普正制药专项(FCK-PZ-09)；王佩娟江苏省名老中医药专家传承工作室项目(20SG2S001) |
|
| 摘要点击次数: 1338 |
| 全文下载次数: 768 |
| 中文摘要: |
| [目的] 采用数据挖掘研究中医治疗早发性卵巢功能不全(premature ovarian insufficiency，POI)的方药规律，并以此为基础分析中医平衡理论在本病诊疗中的实用性和科学性。[方法] 查阅并筛选中国知网(China National Knowledge Infrastructure，CNKI)、万方、维普、PubMed等数据库2016年以来选择中医药治疗POI的期刊论文，将数据录入中医传承辅助平台V2.5，分析用药规律、组方特点及与中医平衡理论的关联性。[结果] 经过筛选共得到处方100首，单味中药使用频次前10位的依序是熟地黄、菟丝子、当归、白芍、山茱萸、山药、枸杞子、香附、甘草、女贞子；性味归经分析显示，常用药物以温性、平性，甘味、苦味为主，多归肝、肾二经。归纳分析处方中药物出现的频次、常用药对，共挖掘出21条核心用药组合，5首新处方。[结论] 肾虚是POI的本质病机，补肾填精法贯穿于治疗的始终，辅以补血养肝、健脾宁心、疏肝调气、活血豁痰等。中医平衡理论凸显并贯穿于治疗始终，关联规则分析可为临床遣方用药提供更坚实的理论支持。 |
| 英文摘要: |
| [Objective] To investigate the modern clinical medication rules for the treatment of premature ovarian insufficiency(POI) by using data mining， and to analyze the practicability and scientificity of the balance theory of traditional Chinese medicine(TCM) in the treatment of this disease. [Methods] The literatures of TCM about the treatment of POI were collected from databases including China National Knowledge Infrastructure(CNKI)， Wanfang， VIP and PubMed from 2016. Using Traditional Chinese Medicine Inheritance Assist System(V2.5)， POI database was set up. Using descriptive analysis， association rules analysis and clustering analysis， the frequency of single drugs， drug combinations prescribed and association rules among drugs were determined as well as the relationship with the balance theory in TCM. [Results] Totally 100 effective formulas were collected. The top ten drugs with the most frequency of prescriptions were Radix Rehmanniae Preparata， Cuscuta chinensis， Angelica sinensis， Radix Paeoniae Alba， Fructus Corni， Rhizoma Dioscoreae， Lycium chinense Miller， Rhizoma Cyperi， Glycyrrhiza uralensis Fisch and Fructus Ligustri Lucidi. The analysis of the nature， taste and meridian tropism of Chinese drugs showed that most of the commonly used drugs were warm， mild， sweet and bitter in nature， and most of them had the meridian tropism of the liver and the kidney meridians. A total of 21 core drug combinations and 5 new prescriptions were found. [Conclusion] Kidney deficiency is the essential pathogenesis of POI， and tonifying the kidney and replenishing essence method is used throughout the treatment. The TCM balance theory stands out and runs through the treatment. The association rule analysis can provide more solid theoretical support for clinical prescription. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |