| 唐允婷,陈宇彬,吴小文,等.非酒精性脂肪肝与单纯性肥胖中医治疗方剂用药规律对比分析[J].浙江中医药大学学报,2023,47(7):804-812. |
| 非酒精性脂肪肝与单纯性肥胖中医治疗方剂用药规律对比分析 |
| Comparative Analysis on Composition Principles of Traditional Chinese Medicine Prescriptions for Non-alcoholic Fatty Liver Disease and Simple Obesity |
| DOI：10.16466/j.issn1005-5509.2023.07.017 |
| 中文关键词: 非酒精性脂肪肝 单纯性肥胖 中医传承计算平台 数据挖掘 中医 用药规律 方剂分析 |
| 英文关键词: non-alcoholic fatty liver disease simple obesity Traditional Chinese Medicine Inheritance Computer System data mining traditional Chinese medicine medication rules prescription analysis |
| 基金项目:海南省基础与应用基础研究计划(自然科学领域)高层次人才项目(2019RC383)；海南省省级中医重点专科建设项目(琼卫中医函﹝2019﹞6号)；海南省重大科技计划项目(ZDKJ2021034) |
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| 中文摘要: |
| [目的] 采用数据挖掘分析对比中医药治疗非酒精性脂肪肝及单纯性肥胖的用药特点及组方规律。[方法] 检索中国知网、万方数据知识服务平台、维普中文期刊服务平台、中国生物医学文献服务系统1984年1月至2021年11月所有中医药治疗上述两种疾病的临床文献，筛选文献和提取资料后，应用中医传承计算平台V3.0及SPSS 23.0软件对方药进行频次统计、关联规则分析及系统聚类分析。[结果] 分别纳入治疗非酒精性脂肪肝和单纯性肥胖的方剂251首和205首，两种疾病在使用补虚药、活血化瘀药时差异有统计学意义(P<0.01)，非酒精性脂肪肝用药多入脾、肝、肺经，特色用药有郁金、虎杖、赤芍、姜黄，关联规则分析得到核心药对是“山楂-泽泻”，聚类分析获得新方的主要功效为健脾祛湿、活血化瘀、疏肝清热。单纯性肥胖用药多入脾、胃、肺经，特色用药有桂枝、生姜，关联规则分析得到核心药对是“茯苓-白术”，聚类分析获得新方的主要功效为健脾祛湿、活血化瘀、行水泄热。[结论] 中医药治疗非酒精性脂肪肝及单纯性肥胖的用药存在共性，两者均重视健脾祛湿，均以泽泻汤为基础进行加减，差异方面，前者以健脾祛湿与活血化瘀并重，佐以疏肝、清热；后者以健脾祛湿为主，佐以活血、清热、疏肝等。 |
| 英文摘要: |
| [Objective] To analyze and compare the characteristics and prescription rules of traditional Chinese medicine in the treatment of non-alcoholic fatty liver disease and simple obesity by data mining. [Methods] Search China National Knowledge Infrastructure(CNKI)， WanFang Data Knowledge Service Platform(Wanfang Database)， VIP Chinese Scientific Journal Database(VIP)， China Biology Medicine disc(CBMdisc) for all the clinical literatures of traditional Chinese medicine in the treatment of the above two diseases from January 1984 to November 2021. After screening the literatures and extracting data， the frequency statistics， association rule analysis and systematic cluster analysis were carried out by using the Traditional Chinese Medicine Inheritance Computer System V3.0 and SPSS 23.0 software. [Results] Totally 251 and 205 prescriptions for the treatment of non-alcoholic fatty liver disease and simple obesity were included respectively， and there was a statistically significant difference in the use of tonic and blood-activating and stasis-removing drugs for the two diseases(P<0.01). Most of the drugs for non-alcoholic fatty liver disease belonged to the spleen， liver and lung meridians， and the characteristic drugs were Curcumae Radix， Polygoni Cuspidati Rhizoma et Radix， Paeoniae Radix Rubra and Curcumae Longae Rhizoma. According to the analysis of association rules， the core drug pair was Crataegi Fructus-Alismatis Rhizoma. Cluster analysis showed that the main effects of the new prescription were tonifying the spleen and removing dampness， invigorating blood circulation and removing blood stasis， soothing the liver and clearing heat. Most of the drugs for simple obesity belonged to the spleen， stomach and lung meridians， and the characteristic drugs are Cinnamomi Ramulus and Zingiberis Rhizoma Recens. According to the analysis of association rules， the core drug pair was PoriaCocos-Atractylodis Macrocephalae Rhizoma. Cluster analysis showed that the main effects of the new prescription were tonifying the spleen and removing dampness， invigorating blood circulation and removing blood stasis， promoting water circulation and releasing heat. [Conclusion] There are similarities in the use of traditional Chinese medicine in the treatment of non-alcoholic fatty liver disease and simple obesity. Both attach importance to tonifying the spleen and removing dampness， and both add and subtract on the basis of Zexie Decoction. In terms of differences， the former focuses on tonifying the spleen and removing dampness， invigorating blood circulation and removing blood stasis， supplemented by soothing the liver and clearing heat; while the latter is mainly treated with drugs for tonifying the spleen and removing dampness， supplemented by invigorating blood circulation， clearing heat， soothing the liver and so on. |
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