| 寿柳梅,陈佳露,邵田娱,等.基于聚类分析的140例中重度手足皮肤反应的中医证型及证型分布特征研究[J].浙江中医药大学学报,2023,47(9):1002-1008. |
| 基于聚类分析的140例中重度手足皮肤反应的中医证型及证型分布特征研究 |
| Study on the TCM Syndromes and Characteristic Distribution: A Cluster Analysis of 140 Patients with Moderate to Severe Hand-foot-skin Reaction |
| DOI：10.16466/j.issn1005-5509.2023.09.004 |
| 中文关键词: 手足皮肤反应 聚类分析 中医证型 证型分布 病因病机 热毒蕴肤证 湿热瘀阻证 血虚风燥证 |
| 英文关键词: hand-foot skin reaction cluster analysis TCM syndromes syndrome distribution etiology and pathogenesis heat-toxin syndrome dampness-heat stasis syndrome blood deficiency and wind-dryness syndrome |
| 基金项目:浙江省中医药科技计划项目(2020ZB076、2022ZB113)；浙江省舒琦瑾名老中医专家传承工作室建设项目(GZS2021024)；浙江中医药大学研究生科学研究基金项目(2021YKJ03) |
|
| 摘要点击次数: 1277 |
| 全文下载次数: 890 |
| 中文摘要: |
| [目的] 探讨中重度手足皮肤反应(hand-foot skin reaction，HFSR)的中医证型及证型分布特征。[方法] 采用临床流行病学研究中的回顾性时间横断面观察法，收集140例中重度HFSR患者的中医证候资料。通过聚类分析方法提取证候资料，得出中重度HFSR患者的中医证型，并进一步分析各证型的分布特征。[结果] 中重度HFSR中医证型分为3类:热毒蕴肤证、湿热瘀阻证、血虚风燥证；进一步从中分析出HFSR的病因病机为热毒、湿、瘀、血虚、风燥5个因素。中医证型频率分析显示，热毒蕴肤证占15.00%，湿热瘀阻证占56.43%，血虚风燥证占28.57%。所有患者平均疼痛数字评分(numerical rating scale，NRS)为(4.45±2.15)分，其中热毒蕴肤证平均NRS评分(4.14±1.35)分，湿热瘀阻证平均NRS评分(5.86±1.34)分，血虚风燥证平均NRS评分(1.83±0.87)分。轻度疼痛以血虚风燥证为主(71.15%)；中、重度疼痛均以湿热瘀阻证(75.44%、93.55%)为主，差异有统计学意义(P<0.01)。[结论] 中重度HFSR临床最常见证型为湿热瘀阻证，血虚风燥证次之，热毒蕴肤证最少见；其中湿热瘀阻证患者的疼痛程度相对较重，而血虚风燥证相对较轻。 |
| 英文摘要: |
| [Objective] To explore the characteristics and distribution of traditional Chinese medicine(TCM) syndromes in patients with moderate to severe hand-foot skin reaction(HFSR). [Methods] The TCM syndromes data of 140 patients with moderate to severe HFSR were collected by retrospective time-cross-sectional observation method in clinical epidemiological research.Cluster analysis was used to analyze the characteristics of TCM syndromes， and it further explored the distribution characteristics in different TCM syndromes. [Results] Patients were classified into three types according to the characteristics of TCM syndromes: heat-toxin syndrome， dampness-heat stasis syndrome， and blood deficiency and wind-dryness syndrome. The etiology and pathogenesis of HFSR were heat-toxin， damp， blood stasis， blood deficiency and wind-dryness. The analysis of TCM syndromes frequencies showed that the heat-toxin syndrome accounted for 15.00%， the dampness-heat stasis syndrome accounted for 56.43%， and the blood deficiency and wind-dryness syndrome accounted for 28.57%. The average numerical rating scale(NRS) score was 4.45±2.15 in all patients. Among them， the average NRS score in heat-toxin syndrome group was 4.14±1.35， the average NRS score in dampness-heat stasis syndrome group was 5.86±1.34， and the average NRS score in blood deficiency and wind-dryness syndrome was 1.83±0.87. In patients with mild pain， blood deficiency and wind-dryness syndrome was the most-common syndrome(71.15%); while in patients with moderate and severe pain， dampness-heat stasis syndrome was account for 75.44% and 93.55% respectively， which showed significant difference in NRS scores among the three groups(P<0.01). [Conclusion] Moderate-to-severe HFSR could be divided into three types. The dampness-heat stasis was the most-common syndrome， followed by the blood deficiency and wind-dryness， and the heat-toxin was the least syndrome. Patients with dampness-heat stasis syndrome were associated with more severe pain than patients with blood deficiency and wind-dryness syndrome. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |