| 刘敏,刘耀丹,陆云飞.玉屏风散加减联合西药治疗促进轻型新冠病毒感染孕妇核酸转阴的疗效观察[J].浙江中医药大学学报,2024,48(1):82-87. |
| 玉屏风散加减联合西药治疗促进轻型新冠病毒感染孕妇核酸转阴的疗效观察 |
| Clinical Observation on the Effect of Modified Yupingfeng Powder Combined with Western Medicine in Promoting Nucleic Acid Negative Transformation of Pregnant Women with Mild COVID-19 |
| DOI：10.16466/j.issn1005-5509.2024.01.014 |
| 中文关键词: 新型冠状病毒感染 中西医结合 玉屏风散加减 孕妇 疗效 妊娠结局 |
| 英文关键词: COVID-19 integrated traditional Chinese and western medicine modified Yupingfeng Powder pregnant women therapeutic effect pregnancy outcome |
| 基金项目:上海市中医药防治新冠肺炎紧急科研立项项目(XGYJKY2022-07) |
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| 中文摘要: |
| [目的] 探讨玉屏风散加减联合西药治疗轻型新冠病毒感染孕妇的临床疗效。[方法] 以上海市公共卫生临床中心2022年4月至6月收治的轻型新冠病毒感染孕妇作为研究对象，随机分成治疗组(48例)及对照组(52例)。对照组给予退热、止咳对症及维生素C等西药治疗，治疗组在对照组基础上给予玉屏风散加减治疗。对比两组患者治疗前后的各症状积分、不良妊娠结局发生率、总有效率和淋巴细胞、C反应蛋白、白细胞介素-2受体、白细胞介素-6等实验室指标变化，并观察两组患者病毒核酸转阴和疾病转归情况。[结果] 与对照组比较，治疗组症状总积分显著下降(P<0.001)，总有效率显著升高(P<0.01)，炎症指标C反应蛋白、白细胞介素-6水平较前显著下降(P<0.001，P<0.01)，而淋巴细胞计数较前显著升高(P<0.001)，不良妊娠结局发生率两组间差异无统计学意义(P>0.05)。[结论] 玉屏风散加减联合西药治疗可显著改善轻型新冠病毒感染孕妇的临床症状，缩短核酸转阴时间，且不会增加不良妊娠结局，具有一定的临床价值，值得临床推广应用。 |
| 英文摘要: |
| [Objective] To explore the clinical efficacy of modified Yupingfeng Powder combined with western medicine in the treatment of pregnant women with mild corona virus disease 2019(COVID-19). [Methods] The pregnant women with mild COVID-19 admitted to Shanghai Public Health Clinical Center from April 2022 to June 2022 were divided into treatment group and control group randomly. The control group(52 cases) was treated with western medicine such as Vitamin C， and the treatment group(48 cases) was treated with modified Yupingfeng Powder on the basis of control group. A comparison was made between the two groups in terms of each symptoms scores， incidence of adverse pregnancy outcomes and total effective rate. Besides， the levels of laboratory indicators involving lymphocyte， C reactive protein(CRP)， interleukin-2 receptor(IL-2R) and interleukin-6(IL-6) were also be compared. The negative changes of virus nucleic acid and disease outcome were observed in the two groups. [Results] Compared with control group， after treatment cessation， the total symptom score in treatment group significantly decreased (P<0.001)， and the total effective rate significantly increased(P<0.01). The levels of inflammatory markers including CRP and IL-6 decreased significantly in treatment group(P<0.001，P<0.01)， while the count of lymphocyte increased significantly(P<0.001). Besides， there was no difference in the incidence of adverse pregnancy outcomes between the two groups(P>0.05). [Conclusion] Modified Yupingfeng Powder combined with western medicine can significantly relieve the clinical symptoms of pregnant women with mild COVID-19， while shortening nucleic acid negative conversion time and does not affect the pregnancy outcome， which has certain clinical value and is worthy of clinical application. |
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