| 何婉如,张晓熙,徐长玉,等.黄酮类化合物防治糖尿病及其并发症研究进展[J].浙江中医药大学学报,2024,48(2):241-246. |
| 黄酮类化合物防治糖尿病及其并发症研究进展 |
| Research Progress of Flavonoids in Prevention and Treatment of Diabetes and Its Complications |
| DOI：10.16466/j.issn1005-5509.2024.02.021 |
| 中文关键词: 黄酮 糖尿病 作用机制 研究进展 糖尿病并发症 中医药治疗 |
| 英文关键词: flavonoids diabetes mechanism of action research progress complications of diabetes traditional Chinese medicine treatment |
| 基金项目:浙江省自然科学基金项目(LQ22H280008)；大学生创新创业训练计划项目(202210344021、S202210344015) |
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| 中文摘要: |
| [目的] 总结分析黄酮类化合物防治糖尿病及其并发症的研究进展。[方法] 检索2013年1月至2022年12月Web of Science、PubMed、中国知网、维普、万方等数据库中黄酮类化合物及糖尿病、糖尿病并发症的相关研究报道，归纳总结出黄酮类化合物在糖尿病及糖尿病并发症中的作用。[结果] 研究证实，黄酮类化合物(中药黄酮提取物、柚皮素、高良姜素、山柰酚等)能有效防治糖尿病及由糖尿病引起的视网膜病变、肾病、心肌病、骨质疏松及糖尿病足。整体调节与综合治疗是黄酮类成分的特色，其具有抑制炎症、减少氧化应激、修复线粒体功能、降血糖、改善胰岛素抵抗的作用，并能够通过多条信号通路影响相关因子的表达，从而治疗糖尿病及其并发症。[结论] 多途径、多层次阐述中药黄酮类化合物防治糖尿病及其并发症的药效物质基础、作用机制及构效关系，是开发黄酮类药物亟待解决的关键问题及未来研究的重要方向。 |
| 英文摘要: |
| [Objective] To summarize and analyze the research progress of flavonoids in the prevention and treatment of diabetes mellitus and its complications. [Methods] The role of flavonoids in diabetes mellitus and diabetic complications was summarized by searching the databases of Web of Science， PubMed， China National Knowledge Infrastructure， VIP， Wanfang and others for the reports of flavonoids and diabetes mellitus and diabetic complications from January 2013 to December 2022， and the role of flavonoids in diabetes mellitus and diabetic complications was summarized. [Results] Studies have confirmed that flavonoids(herbal flavonoid extracts， naringenin， galangal， kaempferol， etc.) are effective in preventing and treating diabetes and diabetes-induced retinopathy， nephropathy， cardiomyopathy， osteoporosis and diabetic foot. Overall regulation and comprehensive treatment are the characteristics of flavonoid components， which can inhibit inflammation， reduce oxidative stress， repair mitochondrial function， lower blood glucose， relieve insulin resistance and are able to influence the expression of related factors from multiple signaling pathways， thus treating diabetes and its complications. [Conclusion] The elaboration of the pharmacodynamic material basis， mechanism of action and constitutive relationship of Chinese medicine flavonoids against diabetes mellitus and its complications in multiple ways and at multiple levels are key issues to be solved in the development of flavonoids and an important direction for future research. |
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