文章摘要
韩思维,段行武,刘克帅,等.基于数据挖掘探究中医内治法治疗掌跖脓疱病处方用药规律[J].浙江中医药大学学报,2024,48(5):601-608.
基于数据挖掘探究中医内治法治疗掌跖脓疱病处方用药规律
Study on Internal Prescription Medication of Palmoplantar Pustulosis in Traditional Chinese Medicine Based on Literature Data Mining Exploration
DOI:10.16466/j.issn1005-5509.2024.05.015
中文关键词: 掌跖脓疱病  中医  中药  内治  数据挖掘  用药规律
英文关键词: palmoplantar pustulosis  traditional Chinese medicine  Chinese drug  internal treatment  data mining  medication pattern
基金项目:广东省重点领域研发计划项目(2020B1111100005);北京市财政项目首发专项(PXM2019_026273_000005)
作者单位
韩思维 北京中医药大学东直门医院 北京 100007
北京中医药大学 
段行武 北京中医药大学东直门医院 北京 100007 
刘克帅 北京中医药大学东直门医院 北京 100007
北京中医药大学 
祝佳音 北京中医药大学东直门医院 北京 100007
北京中医药大学 
吴治民 北京中医药大学东直门医院 北京 100007
北京中医药大学 
胡明慧 北京中医药大学东直门医院 北京 100007
北京中医药大学 
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中文摘要:
      [目的] 基于数据挖掘方法分析中医内治掌跖脓疱病的处方用药规律。[方法] 检索中国知识基础设施工程数据库(China National Knowledge Infrastructure,CNKI)、万方数据知识服务平台数据库(Wanfang Data Knowledge Service Platform)、中文科技期刊数据库(China Science and Technology Journal Database)、中国生物医学文献数据库(China Biology Medicine disc,CBMdisc)自建库至2023年6月关于掌跖脓疱病的中医治疗文献,筛选符合纳入标准的处方,进行标准化处理,采取药物功效归类、频次分析、性味归经分析,以及关联规则分析、熵聚类分析的方法进行数据挖掘,分析用药规律。[结果] 掌跖脓疱病的中医内治多选用清热解毒、清热凉血、清热燥湿类药物;最高频出现的中药为土茯苓、生地黄、甘草;性味归经以味苦、性寒,归肝胃二经为主;用药模式关联规则分析中,频次较高的前三位为“生地黄-牡丹皮”“土茯苓-甘草”“金银花-连翘”;组合模式规则分析中,“牡丹皮→生地黄”“连翘→金银花”“白鲜皮→土茯苓”置信度较高;基于熵聚类方剂组方规律分析获得28个潜在核心组合及14个新方。[结论] 中医内治掌跖脓疱病常以清热祛湿为立法核心,选苦寒之药,归经以肝胃二经为主。处方中土茯苓、生地黄的运用,关联配伍中生地黄与牡丹皮、土茯苓与白鲜皮、金银花与连翘的使用极具临床及科研价值。挖掘数据中潜在的、隐性的药物组方规律,可推导出祛湿热兼凉血解毒的核心组合,为中医内治掌跖脓疱病的临床研究与遣方用药提供参考。
英文摘要:
      [Objective] To analyze the prescription medication pattern of internal Chinese drugs for palmoplantar pustulosis(PPP) based on data mining method. [Methods] China National Knowledge Infrastructure(CNKI) , Wanfang Data Knowledge Service Platform, China Science and Technology Journal Database and China Biology Medicine disc(CBMdisc) were searched for literature on traditional Chinese medicine(TCM) treatment of PPP from self-establishment date to June 2023, and prescriptions that met the inclusion criteria were screened, standardized and analyzed by drug efficacy categorization, frequency analysis, nature and flavor channel tropism analysis,association rule analysis and entropy clustering analysis for the patterns of drug use. [Results] In the internal treatment of PPP, the most frequently used drugs are“ clearing heat and detoxifying”“ clearing heat and cooling blood”“ clearing heat and drying dampness”; the most frequently used drugs are Rhizoma Smilacis Glabrae, Rehmannia glutinosa Libosch and Glycyrrhizae Radix et Rhizoma; in the analysis of the association of drug use patterns, the top three drugs with high frequency are Rehmannia glutinosa Libosch-Moutan Cortex, Rhizoma Smilacis Glabrae-Glycyrrhizae Radix et Rhizoma, Lonicerae Japonicae Flos-Forsythia suspensa(Thunb.) Vahl. In the analysis of combination pattern rule, Moutan Cortex→Rehmannia glutinosa Libosch, Forsythia suspensa(Thunb.) Vahl→Lonicerae Japonicae Flos,Dictamnus dasycarpus Turcz→Rhizoma Smilacis Glabrae with high confidence; 28 potential core combinations and 14 new prescriptions were obtained based on entropy clustering formula grouping rule analysis. [Conclusion] The internal treatment of PPP in TCM often focuses on clearing heat and dispelling dampness as the core of treatment, selecting bitter and cold drugs, focusing on the liver and stomach meridians. The use of Rhizoma Smilacis Glabrae and Rehmannia glutinosa Libosch in the prescription, as well as the combination of Rehmannia glutinosa Libosch and Moutan Cortex, Rhizoma Smilacis Glabrae and Dictamnus dasycarpus Turcz, Lonicerae Japonicae Flos and Forsythia suspensa(Thunb.) Vahl, have great clinical and scientific value. By mining potential and implicit drug formulation patterns in the data, a core combination of dispelling dampness and heat as well as cooling blood and detoxifying can be derived, providing reference for clinical research and prescription medication in the internal treatment of PPP in TCM.
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