| 征征,郁悦,王裕星,等.基于数据挖掘与证候分布的中药治疗多囊卵巢综合征用药规律研究[J].浙江中医药大学学报,2024,48(3):358-367. |
| 基于数据挖掘与证候分布的中药治疗多囊卵巢综合征用药规律研究 |
| Study on Medication Regularity of Chinese Medicine for Polycystic Ovary Syndrome Based on Data Mining and Syndrome Distribution |
| DOI：10.16466/j.issn1005-5509.2024.03.019 |
| 中文关键词: 多囊卵巢综合征 数据挖掘 证候 中药 用药规律 辨证论治 |
| 英文关键词: polycystic ovary syndrome data mining syndrome traditional Chinese medicine medication rule syndrome differentiation and treatment |
| 基金项目:国家自然科学基金项目(81674011)；中国中医科学院科技创新工程重大攻关项目(CI2021A02404) |
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| 中文摘要: |
| [目的] 基于证候分布，通过数据挖掘技术探究中药治疗多囊卵巢综合征(polycystic ovarian syndrome，PCOS)的用药规律。[方法] 系统检索中国知网、万方数据平台、维普全文数据库、Web of Science、PubMed建库至今的中药辨证治疗PCOS的随机对照试验，使用Excel2019、SPSS Modeler 18.0、SPSS Statistics 26.0等软件进行数据分析，探究基于证候分布的中药治疗PCOS用药特点及规律。[结果] 最终纳入281篇文献，中药使用频次3 427次，其中脾虚痰湿为涉及最多的证候类型，当归、茯苓、菟丝子等为使用频次最高的中药，处方中药物的用量多在10～20 ?g，补虚药为处方中最常见的功效类型，温、平为最常见的药性，甘、辛为最常见的药味，肝经、肾经、脾经为最常见的药物归经，不同证候下的用药类型亦有不同。对排名前3的证候进行关联规则分析及聚类分析，绘制复杂网络图及树状图，探究不同证候下中药治疗PCOS的特点及规律。[结论] PCOS的临床表现具有高度异质性，治疗总体以补益脾肾、理气化痰祛瘀为主，不同证候患者治疗方式亦不相同，中药辨证治疗PCOS独具优势，疗效显著，临床需在合理辨证的基础上遣方用药。 |
| 英文摘要: |
| [Objective] To explore the medication rule of traditional Chinese medicine(TCM) in the treatment of polycystic ovary syndrome(PCOS) through data mining based on the distribution of syndromes. [Methods] Randomized controlled trials of TCM syndrome differentiation in the treatment of PCOS from CNKI， Wanfang Data Platform， VIP full-text database， Web of Science and PubMed were systematically searched. Excel2019， SPSS Modeler 18.0， SPSS Statistics 26.0 and other softwares were used for data analysis to explore the drug characteristics and rules of TCM treatment of PCOS based on syndrome distribution. [Results] A total of 281 literatures were included， including 3 427 frequent Chinese drugs， among which spleen deficiency phlegm dampness was the most involved syndrome type， and Angelicae Sinensis Radix， Poria cocos， Cuscuta chinensis Lam and so on were the most frequently used Chinese medicines. The amount of prescription drugs was mostly between 10～20 ?g， deficiency tonic drugs were the most common efficacy type in prescription， and warm and plain were the most common drug properties. Sweet and pungent were the most common drug flavors， while liver， kidney and spleen channels were the most common drug normalization channels. Drug types were also different under different syndrome types. Association rule analysis and cluster analysis were conducted on the top 3 syndrome types， and complex network diagram and tree diagram were drawn to explore the characteristics and rules of TCM treatment of PCOS under different syndrome types. [Conclusion] The clinical manifestations of PCOS are highly heterogeneous， and the treatment mainly focuses on tonifying the spleen and kidney， regulating Qi， resolving phlegm and removing blood stasis. The treatment methods of patients with different syndrome types are also different. TCM syndrome differentiation has unique advantages in the treatment of PCOS with significant effects， and the clinical treatment should be based on reasonable syndrome differentiation. |
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