文章摘要
基于数据挖掘的全国名中医范永升教授治疗结缔组织病相关间质性肺病用药规律探析
Analysis on the Drug Use Law of Professor FAN Yongsheng, a National Famous Traditional Chinese Medicine, in the Treatment of Connective Tissue
投稿时间:2019-06-04  修订日期:2019-06-04
DOI:
中文关键词: 间质性肺病  结缔组织病  范永升  中医传承辅助平台  数据挖掘  名老中医学术经验
英文关键词: interstitial lung disease  Connective tissue disease  Yong-sheng fan  An auxiliary platform for TCM inheritance  Data mining  An old doctor of traditional Chinese medicine
基金项目:浙江省中医药科技计划项目青年人才基金
作者单位E-mail
严一微 浙江中医药大学 937711186@qq.com 
李正富 浙江中医药大学附属第二医院  
杜羽 浙江中医药大学  
吴德鸿 浙江中医药大学附属第二医院  
王新昌 浙江中医药大学附属第二医院  
范永升 浙江中医药大学 fyszjtcm@163.com 
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中文摘要:
      [目的]基于中医传承辅助平台,探讨范永升教授治疗结缔组织病相关间质性肺病(CTD-ILD)的用药规律。[方法]采用数据挖掘方法,分析范永升教授治疗CTD-ILD的方剂中药物的使用频次及药物间的关联规律、处方规律等,提炼范永升教授治疗CTD-ILD的学术经验。[结果]范永升教授治疗合并间质性肺病的结缔组织病有系统性红斑狼疮、干燥综合征、硬皮病、皮肌炎、混合性结缔组织病等,并通过对CTD-ILD治疗的201首方剂的分析,共应用中药166味,甘味药物使用频次最多,为89味(53.54%);苦味药物使用频次为77味(46.64%);辛味药物使用频次为67味(40.34%);酸味和咸味药物使用频次较少。使用频次在100以上的中药有5味,分别是茯苓、白术、桔梗、白芍、甘草。常用组合有白术和茯苓;白芍和茯苓;白术和白芍;白术、茯苓和白芍;黄芪、白术和茯苓等。两味中药组合使用频次超过50次,关联置信度大于80%有3对,分别是桂枝与黄芪、桂枝与白芍、桂枝与茯苓。三味中药组合使用频次超过50次,关联置信度大于80%且位于前三位的分别是白术、桂枝对茯苓;桂枝、茯苓对黄芪;桂枝、茯苓对白术。范永升教授临证多以化湿、通络、清热、宣肺、益气阴等为基本治法。[结论]范永升教授治疗CTD-ILD临床经验丰富,常甘温与苦寒药并用,注重调肺,顾护脾胃,兼以理气。
英文摘要:
      [objective] based on the platform of traditional Chinese medicine inheritance assistance, to investigate the medication law of professor fan yongsheng in the treatment of interstitial lung disease (ctd-ild) related to connective tissue disease. [methods] data mining method was used to analyze the frequency of drug use, the law of association between drugs, and the law of prescription in the prescription of professor fan yongsheng''s treatment of ctd-detector, so as to extract professor fan''s academic experience in the treatment of ctd-detector. [results] professor fan yongsheng treated interstitial pulmonary disease with connective tissue diseases including systemic lupus erythematosus, scleroderma, dermatomyositis, mixed connective tissue disease, etc. Through the analysis of 201 prescriptions of ctd-ild-treated, a total of 166 traditional Chinese medicines were used, and the use frequency of sweet medicine was the most, 89 (53.54%). The use frequency of bitter drugs was 77 (46.64%). The use frequency of pungent drugs was 67 (40.34%). Sour and salty drugs were used less frequently. There are 5 kinds of Chinese herbal medicines used more than 100 times, which are poria cocos, atractylodes macrocephala, radix platycodonis, radix paeoniae alba and liquorice respectively. Commonly used combination has atractylodes and tuckahoe; Radix paeoniae alba and poria cocos; Radix atractylodes and paeoniae alba; Atractylodes macrocephala, poria cocos and paeony alba; Astragalus membranaceus, atractylodes macrocephala and poria cocos, etc. The combined use frequency of the two traditional Chinese medicines was more than 50 times, and the associated confidence was more than 80%. There were 3 pairs, namely cassia twig and astragalus membranaceus, cassia twig and white peony, cassia twig and poria cocos. The combined use frequency of the three traditional Chinese medicines was more than 50 times, and the associated confidence was more than 80%. Cassia twig, poria cocos to astragalus; Cassia twig, poria cocos to atractylodes. Professor fan yongsheng''s clinical symptoms are mainly based on the treatment methods of removing dampness, clearing collaterals, clearing heat, promoting lung and benefiting qi and Yin. [conclusion] professor fan yongsheng has rich clinical experience in the treatment of ctd-ililand. In the treatment, it is used in the treatment of cold and bitter, and focuses on regulating lung, protecting spleen and stomach, and regulating qi.
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