文章摘要
NLRP3炎症小体在痛风性关节炎中的作用及中药干预研究进展
Research progress of NLRP3 inflammasome in the treatment of gout arthritis with Chinese medicine intervention
投稿时间:2021-01-25  修订日期:2021-03-13
DOI:
中文关键词: NLRP3炎症小体  痛风性关节炎  中药干预
英文关键词: NLRP3 inflammasome  gouty arthritis  intervention of traditional Chinese Medicine
基金项目:国家自然科学基金项目(82074085,81673656);国家级大学生创新创业训练计划项目(202010344030);浙江省自然科学基金项目(LY21H280006);浙江中医药大学省重点建设高校优势特色学科(中药学)开放基金重点项目(ZYAOXZD2019002)
作者单位邮编
史悦悦 浙江中医药大学药学院 杭州 310053 310053
张晓熙 浙江中医药大学药学院 杭州 310053 
楚秉泉 浙江中医药大学药学院 杭州 310053 
夏道宗 浙江中医药大学药学院 杭州 310053 310053
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中文摘要:
      痛风性关节炎患病率逐年上升且趋于年轻化,严重影响了患者的生活质量。西药主要通过控制炎症进展或降低体内尿酸水平发挥作用,效果明显,但常常伴随严重不良反应。中药治疗痛风性关节炎历史悠久,具有多靶点、多途径的优势,疗效明显且不良反应率低,具有较好的优势和系统研究的价值。NLRP3炎症小体作为固有免疫的重要组成部分,在调节先天免疫系统的炎症激活中起到了重要作用,与代谢紊乱性疾病——痛风密切相关。近年来,有关NLRP3炎症小体在痛风性关节炎中的作用及中药干预的研究较多,本文在回顾近期相关文献的基础上,以NLRP3炎性小体为核心,从中药复方、中药提取物、中药单体三个方面出发,对中药防治痛风性关节炎的作用进行了总结与分析,以期为痛风治疗药物的研发提供参考。
英文摘要:
      The prevalence of gouty arthritis is increasing year by year and tends to be younger, which seriously affects the quality of life of patients. Chemistry medicine mainly works by controlling the progression of inflammation or reducing the level of uric acid in the body. The effect is obvious, but it is often accompanied by serious adverse reactions. Traditional Chinese medicine has a long history in the treatment of gouty arthritis. It has the advantages of multiple targets and pathways, obvious curative effect and low adverse reaction rate. It has good advantages and value of systematic research. As an important part of innate immunity, NLRP3 inflammasome plays an important role in regulating the inflammatory activation of the innate immune system, and is closely related to the metabolic disorder-gout. In recent years, there have been many studies on the role of NLRP3 inflammasome in gouty arthritis and the intervention of traditional Chinese medicine. Based on the review of relevant literature in recent years, this article takes NLRP3 inflammasome as the core and extracts from traditional Chinese medicines. The effects of traditional Chinese medicine on gouty arthritis are summarized and analyzed in three aspects, Chinese medicine compound, Chinese medicine extract and Chinese medicine monomer, in order to provide reference for the development of gout treatment drugs.
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