| 陈继超,沈沉,彭礼清,等.基于数据挖掘的叶天士治疗郁证用药规律探析[J].浙江中医药大学学报,2020,44(10):1023-1028. |
| 基于数据挖掘的叶天士治疗郁证用药规律探析 |
| Analysis of YE Tianshi’s Medication Rule in Treating Depression Syndrome Based on Data Mining |
| DOI：10-16466/j.issn1005-5509-2020-10-021 |
| 中文关键词: 郁证 用药规律 叶天士 临证指南医案 数据挖掘 临床经验 文献研究 |
| 英文关键词: depression syndrome medication rule YE Tianshi Clinical Guideline of Medical Records data mining clinical experience literature research |
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| 中文摘要: |
| [目的]探析叶天士治疗郁证的组方用药规律。[方法]采用数据挖掘方法，对《临证指南医案·郁》中38则医案中的药物进行频数、药效和性味归经的描述性分析，并对其中26味高频药物进行关联规则分析和聚类分析，总结叶氏治疗郁证的临床经验。[结果]共得到处方45首，药物93味，高频药物共26味，主要有茯苓、牡丹皮、当归、郁金、白芍、生姜、栀子、甘草等，常用的药物组合包括“甘草-当归”“薄荷-茯苓”“白芍-甘草-当归”等。药效以补虚药最多；药性以寒、温、平为主；药味苦、甘、辛多见；归肺、心、肝、脾经最多。聚类分析将高频药物分为7组，涉及理气化痰、益气生血、滋阴清热、利水安神等剂。[结论]叶氏治疗郁证主张调畅情志，辨别虚实，善用寒温药物配伍；重视肝脾同调，且疏肝养肝并行；重视理气，多法泻火，气血并治。总结提炼其治疗郁证的学术思想，对临床上郁证的治疗具有参考价值。 |
| 英文摘要: |
| [Objective]To explore the medication rule of YE Tianshi in treating depression syndrome. [Methods]Using data mining methods， a descriptive analysis of the frequency， efficacy， property， taste and meridian distribution of the herbs in 38 medical cases in “Clinical Guidelines of Medical Records·Yu” was conducted， and cluster analysis was developed about the most frequently used 26 herbs， in order to summarize YE Tianshi’s clinical experience in treating depression syndrome. [Results]There were a total of 45 prescriptions， including 93 flavors of herbs. There were 26 high-frequency herbs， mainly including Poria， Moutan Cortex， Angelica Sinensis， Curcumae Radix， Paeoniae Radix Alba， Zingiberis Rhizoma Recens， Gardeniae Fructus， Glycyrrhiza uralensis Fisch and so on. Commonly used drug combinations included “Glycyrrhiza uralensis Fisch-Angelica Sinensis”“Menthae Haplocalycis Herba-Poria”“Paeoniae Radix Alba-Glycyrrhiza uralensis Fisch-Angelica Sinensis” and other drug groups. Among them， tonic supplements were the most used type of herbs. The medicinal properties were mainly cold， warm and calm， while the main medicine tastes were bitter， sweet and spicy. Medicine efficacy in meridians was mainly in lung， heart， liver and spleen. Cluster analysis divided high-frequency herbs into 7 groups， which involved regulating Qi and resolving phlegm， replenishing Qi and blood， nourishing Yin and clearing the heat， and relieving the water and calming the mind. [Conclusion]YE Tianshi advocated regulating emotions， distinguishing deficiency and excess， and making good use of cold and warm herbs， attaching importance to regulate the liver and spleen， and soothing and nourishing the liver， and regulating Qi， purging fire with multiple methods， and treating Qi and blood simultaneously. Summarizing and refining his academic thoughts on treating depression syndrome has reference value for the treatment of depression syndrome in clinic. |
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